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C3175

Sigma-Aldrich

Chloramphenicol-Water Soluble

powder, suitable for cell culture, BioReagent

Sinónimos:

Chloramphenicol, Chlornitromycin, Chlorocid, Chloromycetin, Cloramfenicol, D-(−)-threo-2-Dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol, D-(−)-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, Chloromycetin, D-threo-2,2-Dichloro-N-[β-hydroxy-α-(hydroxymethyl)-4-nitrophenethyl]aceta, Kloramfenikol

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About This Item

Código UNSPSC:
12352207
NACRES:
NA.76

Nombre del producto

Chloramphenicol-Water Soluble, powder, BioReagent, suitable for cell culture

Línea del producto

BioReagent

Nivel de calidad

200

Formulario

powder

técnicas

cell culture | mammalian: suitable

solubilidad

H2O: 50-500 mg/mL (stock solution)
PBS: 50-500 mg/mL (stock solution)
other salt solutions: not recommended

espectro de actividad antibiótica

Gram-negative bacteria
Gram-positive bacteria
mycobacteria
mycoplasma

Modo de acción

protein synthesis | interferes

Aplicación

Chloramphenicol-Water Soluble has been used:

  • as a supplement in Luria-Bertani (LB) medium to culture Escherichia coli
  • as a supplement in LB agar to culture Citrobacter rodentium
  • to culture Toxoplasma gondii

Acciones bioquímicas o fisiológicas

Chloramphenicol is a natural product found in Streptomyces venezuelae. It shows a broad range of antibiotic activity against Gram-negative and Gram-positive bacteria by binding to the peptidyl transferase loop of the ribosomal RNA to block the peptide bond formation.

Envase

Package size based on chloramphenicol

Otras notas

Formulated to contain approx. 100 mg chloramphenicol per gram of powder; balance 2-hydroxypropyl-β-cyclodextrin.
Keep container tightly closed in a dry and well-ventilated place. Light sensitive. Keep in a dry place.

Pictogramas

Health hazardCorrosion
GHS08,GHS05

Palabra de señalización

Danger

Frases de peligro

H318,H351,H361fd

Clasificaciones de peligro

Carc. 2 - Eye Dam. 1 - Repr. 2

Código de clase de almacenamiento

11 - Combustible Solids

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

Equipo de protección personal

Eyeshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificados de análisis (COA)

Lot/Batch Number
0000356268
0000356268
SLCQ7113
0000338177
SLCP8947

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Chloramphenicol palmitate United States Pharmacopeia (USP) Reference Standard

USP

1107300

Chloramphenicol palmitate

A Chatzitakis et al.
Water research, 42(1-2), 386-394 (2007-08-19)
The photocatalytic degradation of Chloramphenicol, an antibiotic drug, has been investigated in aqueous heterogeneous solutions containing n-type oxide semiconductors as photocatalysts. The disappearance of the organic molecule follows approximately a pseudo-first-order kinetics according to the Langmuir-Hinshelwood model. It was observed
D H Burke et al.
Chemistry & biology, 4(11), 833-843 (1998-01-31)
The problem of how macromolecules adopt specific shapes to recognize small molecules in their environment is readily addressed through in vitro selections (the SELEX protocol). RNA-antibiotic interactions are particularly attractive systems for study because they provide an opportunity to expand
Jaap C Hanekamp et al.
Environmental toxicology and pharmacology, 39(1), 213-220 (2014-12-22)
The antibiotic chloramphenicol (CAP) is banned from food production. Besides being a medicinal product, CAP is also a natural product, produced by Streptomyces Venezuelae. The lack of scientific data hampers setting of an Acceptable Daily Intake (ADI). Consequently, a maximum
Valerie F Crepin et al.
Nature protocols, 11(10), 1851-1876 (2016-09-09)
Infection of mice with Citrobacter rodentium is a robust model to study bacterial pathogenesis, mucosal immunology, the health benefits of probiotics and the role of the microbiota during infection. C. rodentium was first isolated by Barthold from an outbreak of
Taru Hilander et al.
Nucleic acids research, 46(2), 849-860 (2017-12-12)
Accuracy of protein synthesis is enabled by the selection of amino acids for tRNA charging by aminoacyl-tRNA synthetases (ARSs), and further enhanced by the proofreading functions of some of these enzymes for eliminating tRNAs mischarged with noncognate amino acids. Mouse
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