C3045

Colesterol

powder, BioReagent, suitable for cell culture, ≥99%

• Sinónimos: 3β-Hidroxi-5-colesteno, 5-Colesten-3β-ol
• Fórmula empírica (notación de Hill): C₂₇H₄₆O
• Número de CAS: 57-88-5
• Peso molecular: 386.65
• Beilstein: 1915888
• Número CE: 200-353-2
• Número MDL: MFCD00003646
• Código UNSPSC: 12352211
• eCl@ss: 39023139
• ID de la sustancia en PubChem: 24892329
• NACRES: NA.75

Propiedades

• origen biológico: ovine wool
• Línea del producto: BioReagent
• Ensayo: ≥99%
• Formulario: powder
• técnicas: cell culture | mammalian: suitable
• bp: 360 °C (lit.)
• mp: 147-149 °C (lit.)
• solubilidad: H₂O: 0.002 mg/mL; Tween: soluble; ethanol: soluble; serum: soluble
• densidad: 1.067 g/mL at 25 °C (lit.)
• Condiciones de envío: ambient
• temp. de almacenamiento: −20°C
• cadena SMILES: CC(C)CCC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3CC=C4C[C@@H](O)CC[C@]4(C)[C@H]3CC[C@]12C
• InChI: 1S/C27H46O/c1-18(2)7-6-8-19(3)23-11-12-24-22-10-9-20-17-21(28)13-15-26(20,4)25(22)14-16-27(23,24)5/h9,18-19,21-25,28H,6-8,10-17H2,1-5H3/t19-,21+,22+,23-,24+,25+,26+,27-/m1/s1
• Clave InChI: HVYWMOMLDIMFJA-DPAQBDIFSA-N
• Información sobre el gen: human ... POLA1(5422) , TOP2A(7153) ; rat ... Ar(24208) , Polb(29240)

Descripción

Descripción general

Cholesterol, a major sterol is the precursor for steroid hormones, bile acid and vitamin in mammals and coordinates endocytosis. It complexes with protein to form lipoproteins for transport in blood. It exists either as high-density lipoprotein (HDL) or low-density lipoprotein (LDL). HDL also called good cholesterol has less lipid content. LDL or bad cholesterol has high lipid content. Statin inhibition of HMG-CoA reductase enzyme in the cholesterol biosynthesis pathway controls elevated cholesterol levels in atherosclerosis and hypercholesterolemia. Low levels of cholesterol results in hypothyroidism, familial hypobetalipoproteinemia and liver disease. Imbalance of cholesterol homeostasis and intracellular cholesterol levels play a key role in cancer development. High cholesterol levels favor breast cancer progression.

Aplicación

Cholesterol has been used:

• as a medium supplement in chorionic villous tissue culture form placenta
• as a component of hormone pellet for implantation in mice ovary
• for inducing expression of immunity-related GTPase M (IRGM) in human monocytic cell line, THP-1

Acciones bioquímicas o fisiológicas

Componente principal de todas las membranas biológicas; ~ el 25 % de todos los lípidos cerebrales es colesterol.

Información de seguridad

• Código de clase de almacenamiento: 11 - Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable
• Equipo de protección personal: Eyeshields, Gloves, type N95 (US)