Saltar al contenido
Merck
Todas las fotos(2)

Documentos

B019

Sigma-Aldrich

Phenoxybenzamine hydrochloride

≥97%, powder

Sinónimos:

N-(2-Chloroethyl)-N-(1-methyl-2-phenoxyethyl)benzylamine hydrochloride

Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
Todas las fotos(2)

About This Item

Fórmula empírica (notación de Hill):
C18H22ClNO · HCl
Número de CAS:
63-92-3
Peso molecular:
340.29
EC Number:
200-569-7
MDL number:
MFCD00055152
UNSPSC Code:
12352116
PubChem Substance ID:
24277760
NACRES:
NA.77

Quality Level

100

assay

≥97%

form

powder

color

white

solubility

H2O: slightly soluble
alcohol: soluble
propylene glycol: soluble

originator

Wellspring

storage temp.

2-8°C

SMILES string

Cl[H].CC(COc1ccccc1)N(CCCl)Cc2ccccc2

InChI

1S/C18H22ClNO.ClH/c1-16(15-21-18-10-6-3-7-11-18)20(13-12-19)14-17-8-4-2-5-9-17;/h2-11,16H,12-15H2,1H3;1H

InChI key

VBCPVIWPDJVHAN-UHFFFAOYSA-N

Gene Information

human ... ADRA1A(148) , ADRA1B(147) , ADRA1D(146) , ADRA2A(150) , ADRA2B(151) , ADRA2C(152)

¿Está buscando productos similares? Visita Guía de comparación de productos

Biochem/physiol Actions

Calmodulin antagonist; α-adrenoceptor antagonist.

Features and Benefits

This compound is a featured product for ADME Tox research. Click here to discover more featured ADME Tox products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Wellspring. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

pictograms

Health hazardExclamation mark
GHS08,GHS07

signalword

Warning

hcodes

H302,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificados de análisis (COA)

Busque Certificados de análisis (COA) introduciendo el número de lote del producto. Los números de lote se encuentran en la etiqueta del producto después de las palabras «Lot» o «Batch»

¿Ya tiene este producto?

Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.

Visite la Librería de documentos

Katsuhisa Morita et al.
Scientific reports, 10(1), 13139-13139 (2020-08-06)
Chemicals have multiple effects in biological systems. Because their on-target effects dominate the output, their off-target effects are often overlooked and can sometimes cause dangerous adverse events. Recently, we developed a novel decomposition profile data analysis method, orthogonal linear separation
Hasan K Siddiqi et al.
Surgery, 152(6), 1027-1036 (2012-11-20)
Calcium channel blockade with nicardipine (NC) is an alternative to phenoxybenzamine (PB) preparation for resection of a pheochromocytoma. Intraoperative magnesium sulfate infusion (+MgSO(4)) is often used for its cardiovascular stabilizing properties. We hypothesized that preparation with NC would be similar
Y M Ning et al.
Molecular endocrinology (Baltimore, Md.), 10(1), 14-23 (1996-01-01)
The glucocorticoid receptor (GR) is a ligand-regulated transcription factor whose ability to bind hormone is thought to be dependent on association with the 90-kDa heat shock protein (hsp90). In the present study, we have generated a novel form of the
P A van Zwieten et al.
Annals of the New York Academy of Sciences, 522, 351-360 (1988-01-01)
A survey is given of the interaction between alpha-adrenoceptor-triggered vasoconstriction and the influx of extracellular calcium ions. This problem was investigated by studying the influence of calcium entry blockers (CEB) on the vasoconstriction induced by several types of alpha 2-
Elif Cadirci et al.
Critical care medicine, 38(9), 1860-1867 (2010-07-06)
Adrenal gland hormones have been shown to have a role in the antiinflammatory effect mechanism of nonsteroidal antiinflammatory drugs. This study investigates whether the analgesic effects of indomethacin, diclofenac sodium, aspirin, and nimesulide (IDAN; upper case letters of the four
Ver todos los artículos relacionados

Artículos

Discover Bioactive Small Molecules for ADME/Tox

Discover Bioactive Small Molecules for ADME/Tox

Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.

Póngase en contacto con el Servicio técnico