A9546
2-Amino-6-methylmercaptopurine
≥95%
Sinónimos:
2-Amino-6-methylthiopurine
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Acerca de este artículo
Fórmula empírica (notación de Hill):
C6H7N5S
Número CAS:
Peso molecular:
181.22
NACRES:
NA.51
PubChem Substance ID:
UNSPSC Code:
41106305
EC Number:
214-833-4
MDL number:
Assay:
≥95%
Form:
solid
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Permítanos ayudarleQuality Level
assay
≥95%
form
solid
SMILES string
[H]n1cnc2c(SC)nc(N)nc12
InChI
1S/C6H7N5S/c1-12-5-3-4(9-2-8-3)10-6(7)11-5/h2H,1H3,(H3,7,8,9,10,11)
InChI key
YEGKYFQLKYGHAR-UHFFFAOYSA-N
Application
2-Amino-6-methylmercaptopurine is a 2-amino-6-alkyldithiopurine that has been used with other 6-position carbon analogues to study brain specific diazepam binding.
2-Amino-6-methylmercaptopurine (6-MTG) has been used as a supplement in Dulbecco′s modified Eagles medium (DMEM) medium for the selection of gpt-expressing recombinant virus mCMVhMIEPE-gpt.lacZ (cytomegalovirus major immediate-early promotor-enhancer complex-gpt.lacz). It has also been used as a standard in high performance liquid chromatography (HPLC) to assess the activity of thiopurine methyltransferase (TPMT) enzyme.
Biochem/physiol Actions
2-Amino-6-methylmercaptopurine is synthesized from 6-mercaptopurine by the S methylation activity of thiopurine methyl transferase (TMPT) enzyme.
signalword
Danger
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Clase de almacenamiento
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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S C Sung et al.
Biochemical pharmacology, 33(11), 1737-1739 (1984-06-01)
Various derivatives of 2-amino-6- methylthiopurine with substituents at the 6-position of purine were tested for their abilities to displace [3H]diazepam binding to rat brain membranes. The potency was dependent on the carbon chain-length in the 6-position of purine. Among the
Effect of 9-alkyl derivatives of 6-methylthioguanine on brain specific binding of [3H]diazepam.
S C Sung et al.
Biochemical pharmacology, 35(20), 3645-3646 (1986-10-15)
A Practical Non-Extraction Direct Liquid Chromatography Method for Determination of Thiopurine S-Methyltransferase Activity in Inflammatory Bowel Disease
Bahrehmand F, et al.
Acta Medica Iranica, 55(6), 360-367 (2017)
G R Erdmann et al.
Biomedical chromatography : BMC, 4(2), 47-51 (1990-03-01)
A reversed phase high performance liquid chromatographic procedure was developed to quantify 6-thioguanine, 6-mercaptopurine, methylthioguanine, and methylmercaptopurine in red blood cells. The free base of each thiopurine was liberated from the respective nucleoside and nucleotide moiety by acid hydrolysis, which
S C Sung et al.
European journal of pharmacology, 81(3), 505-508 (1982-07-16)
We have compared fifteen synthetic purines and purine nucleosides on their ability to displace [3H]diazepam binding to rat brain membranes. Among these analogs, 6-methylthioguanine was found to be most potent, inhibiting competitively the specific binding of [3H]diazepam with a Ki
Número de artículo de comercio global
| SKU | GTIN |
|---|---|
| A9546-100MG | 04061833045381 |
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