A7127

Agmatine sulfate salt

≥97% (TLC), powder, ion channel blocker

• Sinónimos: 1-Amino-4-guanidinobutane sulfate salt, 4-Guanidinobutylamine sulfate salt, N-(4-Aminobutyl)guanidine sulfate salt
• Fórmula lineal: H₂N(CH₂)₄NHC(=NH)NH₂·H₂SO₄
• Número de CAS: 2482-00-0
• Peso molecular: 228.27
• Beilstein/REAXYS Number: 3918807
• EC Number: 219-617-3
• MDL number: MFCD00013109
• UNSPSC Code: 12352200
• PubChem Substance ID: 24277749
• NACRES: NA.32

Propiedades

• Nombre del producto: Agmatine sulfate salt, ≥97%, powder
• Quality Level: 100
• assay: ≥97%
• form: powder
• color: white to off-white
• mp: 234-238 °C (lit.)
• solubility: H₂O: 50 mg/mL; ethanol: insoluble
• SMILES string: OS(O)(=O)=O.NCCCCNC(N)=N
• InChI: 1S/C5H14N4.H2O4S/c6-3-1-2-4-9-5(7)8;1-5(2,3)4/h1-4,6H2,(H4,7,8,9);(H2,1,2,3,4)
• InChI key: PTAYFGHRDOMJGC-UHFFFAOYSA-N
• Gene Information: human ... ADRA2A(150) , ADRA2B(151) , ADRA2C(152) , GRIN1(2902) , GRIN2A(2903) , GRIN2B(2904) , GRIN2C(2905) , GRIN2D(2906) , GRINA(2907)

Descripción

Application

Agmatine sulfate salt has been used:

• to study its effects on nod-like receptor protein 3 (NLRP3) inflammasome activation and cytokine responses in sub-chronic restraint stress rat models[1]
• as an N-methyl-D-aspartate (NMDA) receptor blocker to study its therapeutic effects on autistic behaviors in the valproic acid-induced animal model of autism[2]
• as a standard to determine the bioactive amines in vegetables by high-performance liquid chromatography (HPLC)[3]

Biochem/physiol Actions

Agmatine is a decarboxylated arginine that is present ubiquitously in all living organisms.[4] It is found in food sources such as plant source food and animal products.[5] It exhibits cryoprotective effects against several body functions such as nephroprotection, neuroprotection, gastroprotection, and cardioprotection. Agmatine also exhibits therapeutic effects against neurotrauma, neuropathic pain, diabetes, neurodegenerative diseases, and psychiatric diseases.[4] It is involved in blocking many ionic channels such as ATP-sensitive K⁺ channels and voltage-gated Ca²⁺ channels. Agmatine modulates nitric oxide production and inhibits matrix metalloproteases.[5]

Putative endogenous neurotransmitter at imidazoline receptors; displaces clonidine at α₂-adrenergic and at imidazoline receptors; blocks NMDA-activated ion channels in hippocampal neurons.

Información de seguridad

• Storage Class: 11 - Combustible Solids
• wgk_germany: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)