A0326

(S)-AMPA

≥97%, AMPA receptor agonist, powder

• Sinónimos: (S)-α-Amino-3-hydroxy-5-methylisoxazole-4-propionic acid
• Fórmula empírica (notación de Hill): C₇H₁₀N₂O₄
• Número CAS: 83643-88-3
• Peso molecular: 186.17
• UNSPSC Code: 12352200
• PubChem Substance ID: 24890421
• NACRES: NA.77
• MDL number: MFCD00672630
• Assay: ≥97%
• Form: powder

Propiedades

• Nombre del producto: (S)-AMPA, ≥97%
• Quality Segment: 100
• assay: ≥97%
• form: powder
• SMILES string: Cc1onc(O)c1C[C@H](N)C(O)=O
• InChI: 1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)/t5-/m0/s1
• InChI key: UUDAMDVQRQNNHZ-YFKPBYRVSA-N
• Gene Information: human ... GRIA1(2890), GRIA2(2891), GRIA4(2893), GRIK1(2897) ; mouse ... Gria1(14799) ; rat ... Gria1(50592), Gria2(29627), Gria3(29628), Gria4(29629), Grik1(29559), Grik2(54257), Grik4(24406), Grin2a(24409), Grin2b(24410), Grm6(24419)

Descripción

General description

AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid) activates excitatory postsynaptic currents (EPSC).

Application

(S)-AMPA has also been used to activate rostromedial tegmental nucleus (RMTg), to study aversive conditioning in relation with cocaine-induced avoidance behaviors in mice.

(S)-AMPA has been used to selectively eliminate the neural cochlear component of adult barn owls by destroying afferent synapses.

Biochem/physiol Actions

Active enantiomer of (RS)-AMPA zwitterion. Potent agonist at the AMPA subclass of ionotropic glutamate receptors.

Potent agonist at the AMPA subclass of ionotropic glutamate receptors; active enantiomer.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)