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Y0000326

Azelastine hydrochloride

European Pharmacopoeia (EP) Reference Standard

Sinónimos:

4-[(4-chlorophenyl)methyl]-2-(1-methylazepan-4-yl)phthalazin-1-one hydrochloride, Astelin, Optivar

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About This Item

Fórmula empírica (notación de Hill):
C22H24ClN3O · HCl
Número de CAS:
79307-93-0
Peso molecular:
418.36
Número MDL:
MFCD00242783
Código UNSPSC:
41116107
ID de la sustancia en PubChem:
329830908
NACRES:
NA.24

grado

pharmaceutical primary standard

familia API

azelastine

fabricante / nombre comercial

EDQM

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

Cl.CN1CCCC(CC1)N2N=C(Cc3ccc(Cl)cc3)c4ccccc4C2=O

InChI

1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H

Clave InChI

YEJAJYAHJQIWNU-UHFFFAOYSA-N

Información sobre el gen

human ... HRH1(3269)

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Descripción general

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the Issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Aplicación

Azelastine hydrochloride EP Reference standard, intended for use in laboratory tests only as specifically prescribed in the European Pharmacopoeia.

Acciones bioquímicas o fisiológicas

H1 histamine receptor antagonist; NF-kB activator.

Envase

The product is delivered as supplied by the issuing Pharmacopoeia. For the current unit quantity, please visit the EDQM reference substance catalogue.

Otras notas

Sales restrictions may apply.

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Y0000327

Azelastine impurity B, European Pharmacopoeia (EP) Reference Standard

Y0000328

Azelastine impurity D, European Pharmacopoeia (EP) Reference Standard

Y0000329

Azelastine impurity E, European Pharmacopoeia (EP) Reference Standard

1046158

Azelastine hydrochloride, United States Pharmacopeia (USP) Reference Standard

1046191

Azelastine Related Compound D, United States Pharmacopeia (USP) Reference Standard

1046202

Azelastine Related Compound E, United States Pharmacopeia (USP) Reference Standard

1046170

Azelastine Related Compound B, United States Pharmacopeia (USP) Reference Standard

1046213

Azelastine Related Compound F, United States Pharmacopeia (USP) Reference Standard

PHR2842

Azelastine Related Compound D

PHR2843

Azelastine Related Compound E, certified reference material, pharmaceutical secondary standard

Pictogramas

Exclamation mark
GHS07

Palabra de señalización

Warning

Frases de peligro

H302

Consejos de prudencia

P301 + P312 + P330

Clasificaciones de peligro

Acute Tox. 4 Oral

Código de clase de almacenamiento

11 - Combustible Solids

Punto de inflamabilidad (°F)

Not applicable

Punto de inflamabilidad (°C)

Not applicable

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Certificados de análisis (COA)

Lot/Batch Number

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Tsugunobu Andoh et al.
Journal of pharmacological sciences, 114(3), 292-297 (2010-10-16)
Recently, we showed that a methanol extract of Ganoderma lucidum inhibits scratching, an itch-related response, induced by intradermal injections of some pruritogens in mice. The present study investigated whether G. lucidum extract would inhibit allergic itch. In mice sensitized with
Eli O Meltzer et al.
Allergy and asthma proceedings, 33(4), 324-332 (2012-08-04)
Many patients with allergic rhinitis (AR) have uncontrolled symptoms despite available treatment options. This study was designed to evaluate the efficacy and safety of MP29-02 (a novel intranasal formulation of fluticasone propionate [FP] and azelastine [AZ] hydrochloride), compared with monotherapy
Carsten Gründemann et al.
Journal of ethnopharmacology, 145(1), 118-126 (2012-11-13)
Extracts from Veronica officinalis L. are traditionally used for the treatment of lung diseases; however, the effective compounds and the mode of action are still unknown. Here we analyzed the effects of a standardized Veronica extract on genes expression and
Panayiotis A Procopiou et al.
Bioorganic & medicinal chemistry, 20(20), 6097-6108 (2012-09-19)
5-Aza, 6-aza, 7-aza and 8-aza-phthalazinone, and 5,8-diazaphthalazinone templates were synthesised by stereoselective routes starting from the appropriate pyridine/pyrazine dicarboxylic acids by activation with CDI, reaction with 4-chlorophenyl acetate ester enolate to give a β-ketoester, which was hydrolysed, and decarboxylated. The
L-L Fu et al.
Cell proliferation, 47(4), 326-335 (2014-06-27)
The aim of this study was to explore sodium taurocholate co-transporting polypeptide (NTCP) exerting its function with hepatitis B virus (HBV) and its targeted candidate compounds, in HBV therapy. Identification of NTCP as a novel HBV target for screening candidate
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