SYNPLE-P003

Reagent-cartridge CRBN-PEG₃

Synple

• Sinónimos: Synple 2
• Número MDL: MFCD32903606
• Código UNSPSC: 12161503
• NACRES: NA.22

Propiedades

• ligand: pomalidomide
• Nivel de calidad: 100
• Parámetros: up to 0.1 mmol scale
• cadena SMILES: [s]1cnc(c1c2ccc(cc2)CNC(=O)[C@H]3N(C[C@@H](C3)O)C(=O)[C@@H](NC(=O)CCOCCC(=O)O)C(C)(C)C)C
• InChI: 1S/C28H38N4O7S/c1-17-24(40-16-30-17)19-7-5-18(6-8-19)14-29-26(37)21-13-20(33)15-32(21)27(38)25(28(2,3)4)31-22(34)9-11-39-12-10-23(35)36/h5-8,16,20-21,25,33H,9-15H2,1-4H3,(H,29,37)(H,31,34)(H,35,36)/t20-,21+,25-/m1/s1
• Clave InChI: HVPZHRHEHKZOOJ-TYBLODHISA-N

Descripción

Descripción general

Reagent-cartridge CRBN-PEG₃ is a reagent cartridge for the Synple 2 Automated Synthesizer that enables the synthesis of molecules for targeted protein degradation and PROTAC^® (proteolysis-targeting chimeras) research. The cartridge contains all necessary reagents for linking the user selected aldehyde or ketone to the amine terminated linker through a reductive amination. This cartridge features a Cereblon (CRBN) recruiting ligand (pomalidomide) and PEG linker. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and degrader, many analogs are prepared to screen for optimal target degradation.

Scale: up to 0.1 mmol
Linker: PEG₃
E3 ligase target and ligand: Cereblon (CRBN), pomalidomide
Terminal functional group: amine
Compatible substrates: ketone, aldehyde

Cartridge contents:

• Reducing agent (supported cyanoborohydride)
• Base (supported triethylamine)
• SCX (for purification)
• Degrader building block linker reagent

Related Cartridges:

• SYNPLE-P001Reagent-cartridge CRBN-PEG₁
• SYNPLE-P002Reagent-cartridge CRBN-PEG₂
• SYNPLE-P004Reagent-cartridge CRBN-PEG₄
• SYNPLE-P005Reagent-cartridge CRBN-PEG₅
• SYNPLE-P021Reagent-cartridge VHL-PEG₁
• SYNPLE-P022Reagent-cartridge VHL-PEG₂
• SYNPLE-P023Reagent-cartridge VHL-PEG₃
• SYNPLE-P024Reagent-cartridge VHL-PEG₄
• SYNPLE-P025Reagent-cartridge VHL-PEG₅

Learn more about the Synple automated synthesis platform.

Learn more about protein degradation.

Explore all our Protein Degrader Building Blocks

Features and Benefits of Synple Platform

• Time savings - pre-installed protocols have been highly optimized, which obviates the need for the user′s own reaction development and optimization
• Easy to use - protocols are loaded by simply scanning the cartridge; does not requires any programming knowledge
• Safety - all chemicals are contained in the system, minimizing the user′s exposure
• Set-up reaction in less than 5 minutes
• Small footprint
• Plug & Play system - simple installation
• Reaction temperatures from 25 °C - 80 °C
• Cartridges available for many different reactions
• Prefilled with all required reagents
• RFID chip containing optimized reaction protocol

Otras notas

An integrated console for capsule-based, automated organic synthesis

Información legal

Product of Synple Chem AG

PROTAC is a registered trademark of Arvinas Operations, Inc., and is used under license

Información de seguridad

• Pictogramas: GHS07
• Palabra de señalización: Warning
• Frases de peligro: H315,H319
• Consejos de prudencia: P264 - P280 - P302 + P352 - P305 + P351 + P338 - P332 + P313 - P337 + P313
• Clasificaciones de peligro: Eye Irrit. 2 - Skin Irrit. 2
• Código de clase de almacenamiento: 13 - Non Combustible Solids
• Clase de riesgo para el agua (WGK): WGK 3
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable