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PHR1028

Supelco

p-Benzoquinona

Pharmaceutical Secondary Standard; Certified Reference Material

Sinónimos:

Quinona

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About This Item

Fórmula lineal:
C6H4(=O)2
Número de CAS:
106-51-4
Peso molecular:
108.09
Beilstein:
773967
Número CE:
203-405-2
Número MDL:
MFCD00001591
Código UNSPSC:
12352005
ID de la sustancia en PubChem:
329823058
NACRES:
NA.24

grado

certified reference material
pharmaceutical secondary standard

Nivel de calidad

300

Agency

traceable to USP 1056504

densidad de vapor

3.73 (vs air)

presión de vapor

0.1 mmHg ( 25 °C)

CofA

current certificate can be downloaded

temp. de autoignición

815 °F

técnicas

HPLC: suitable
gas chromatography (GC): suitable

mp

113-115 °C (lit.)

aplicaciones

pharmaceutical (small molecule)

Formato

neat

temp. de almacenamiento

2-8°C

cadena SMILES

O=C1C=CC(=O)C=C1

InChI

1S/C6H4O2/c7-5-1-2-6(8)4-3-5/h1-4H

Clave InChI

AZQWKYJCGOJGHM-UHFFFAOYSA-N

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Descripción general

1,4-Benzoquinone is a cyclic conjugated diketone. It belongs to the class of quinones, naturally occurring in plants, fungi, and bacteria.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

Aplicación

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

Nota de análisis

These secondary standards offer multi-traceability to the USP, EP (PhEur) and BP primary standards, where they are available.

Otras notas

This Certified Reference Material (CRM) is produced and certified in accordance with ISO 17034 and ISO/IEC 17025. All information regarding the use of this CRM can be found on the certificate of analysis.

Nota al pie de página

To see an example of a Certificate of Analysis for this material enter LRAB7811 in the slot below. This is an example certificate only and may not be the lot that you receive.

Productos recomendados

Find a digital Reference Material for this product available on our online platform ChemisTwin® for NMR. You can use this digital equivalent on ChemisTwin® for your sample identity confirmation and compound quantification (with digital external standard). An NMR spectrum of this substance can be viewed and an online comparison against your sample can be performed with a few mouseclicks. Learn more here and start your free trial.

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Flam. Sol. 1 - Muta. 2 - Skin Corr. 1B - Skin Sens. 1 - STOT SE 3

Órganos de actuación

Respiratory system

Código de clase de almacenamiento

4.1B - Flammable solid hazardous materials

Clase de riesgo para el agua (WGK)

WGK 3

Punto de inflamabilidad (°F)

170.6 °F - closed cup

Punto de inflamabilidad (°C)

77 °C - closed cup

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Certificados de análisis (COA)

Lot/Batch Number

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Sacarosa United States Pharmacopeia (USP) Reference Standard

USP

1623637

Sacarosa

4-Nitrophenol ReagentPlus®, ≥99%

Sigma-Aldrich

241326

4-Nitrophenol

TOC-Calibration Kit 25 mg TOC

A-2045-040

TOC-Calibration Kit

Sacarosa meets USP testing specifications

Sigma-Aldrich

S3929

Sacarosa

Quinone chemistry and toxicity
Monks JT, et al.
Toxicology and Applied Pharmacology, 112(1), 2-16 (1992)
Rozbeh Baradaran et al.
Nature, 494(7438), 443-448 (2013-02-19)
Complex I is the first and largest enzyme of the respiratory chain and has a central role in cellular energy production through the coupling of NADH:ubiquinone electron transfer to proton translocation. It is also implicated in many common human neurodegenerative
Takafumi Hasegawa et al.
Journal of neurochemistry, 87(2), 470-475 (2003-09-27)
Oxidized metabolites of dopamine, known as dopamine quinone derivatives, are thought to play a pivotal role in the degeneration of dopaminergic neurons. Although such quinone derivatives are usually produced via the autoxidation of catecholamines, tyrosinase, which is a key enzyme
Vandana Bhalla et al.
Dalton transactions (Cambridge, England : 2003), 42(13), 4464-4469 (2013-02-16)
The binding behavior of nanoaggregates of pentacenequinone derivative 1 having thiophene groups has been investigated toward various cations (Fe(3+), Fe(2+), Pd(2+), Mg(2+), Cd(2+), Hg(2+), Ni(2+), Zn(2+), Cu(2+), Pb(2+), Co(2+), K(+), Na(+) and Li(+)) using UV-vis and fluorescence spectroscopy. Among the
K He et al.
Biochemical pharmacology, 62(2), 191-198 (2001-06-08)
Oxidative ring opening of troglitazone (TGZ)(1) a thiazolidine 2,4-dione derivative used for the treatment of type II diabetes mellitus, leads to the formation of a quinone metabolite. The formation of TGZ quinone was shown to be NADPH dependent and to
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