The primary difference between the products is the testing. Product P0972 is USP tested, product P4932 is tested against 3 mammalian cell lines to make sure it is not toxic to the cells, product P4119 is cell culture and endotoxin tested, and products P1004 and 81334 are the research grades with P1004 in USP units and 81334 in international units.
P0972
Polymyxin B sulfate
meets USP testing specifications
Sinónimos:
Polymyxin B sulfate salt
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1000000 UNITS
$88.500
10000000 UNITS
$439.000
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$1.550.000
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1000000 UNITS
$88.500
10000000 UNITS
$439.000
50000000 UNITS
$1.550.000
About This Item
Fórmula empírica (notación de Hill):
C55H96N16O13 · 2H2SO4
Número de CAS:
Peso molecular:
1385.61
EC Number:
MDL number:
UNSPSC Code:
12352209
NACRES:
NA.21
Productos recomendados
agency
USP/NF
meets USP testing specifications
Quality Level
form
powder
antibiotic activity spectrum
Gram-negative bacteria
Gram-positive bacteria
fungi
application(s)
pharmaceutical (small molecule)
mode of action
cell membrane | interferes
storage temp.
2-8°C
SMILES string
O=C(C(NC(C(CCN)NC(CCCCC(C)CC)=O)=O)C(C)O)NC(CCN)C(NC(CCNC(C(NC(C(NC(C(CCN)N1)=O)CCN)=O)C(O)C)=O)C(NC(CCN)C(NC(CC2=CC=CC=C2)C(NC(CC(C)C)C1=O)=O)=O)=O)=O.O=S(O)(O)=O
InChI
1S/C48H82N16O13.H2O4S/c1-27(2)24-37-47(76)59-32(11-19-52)41(70)56-31(10-18-51)43(72)61-35(14-22-65)39(68)54-21-13-34(45(74)57-33(12-20-53)44(73)64-38(48(77)63-37)25-28-6-4-3-5-7-28)60-42(71)30(9-17-50)58-46(75)36(15-23-66)62-40(69)29(8-16-49)55-26-67;1-5(2,3)4/h3-7,26-27,29-38,65-66H,8-25,49-53H2,1-2H3,(H,54,68)(H,55,67)(H,56,70)(H,57,74)(H,58,75)(H,59,76)(H,60,71)(H,61,72)(H,62,69)(H,63,77)(H,64,73);(H2,1,2,3,4)
InChI key
HNDFYNOVSOOGDU-UHFFFAOYSA-N
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Categorías relacionadas
General description
Chemical structure: peptide
Application
Polymyxin B sulfate is a strongly cationic cyclic polypeptide antibiotic that is derived from fermentation of Bacilus polymyxa. It is a mixture of B1 and B2 sulfate. The product has been used clinically to treat infections of the urinary tract, meninges and blood stream caused by susceptible strains of Pseudomonas aeruginosa. It also has uses studying multidrug-resistant pathogens, as an immobilized agent for removal of endotoxins, and to induce pore formation in the membranes of cortex cells from excised sorghum roots.
Biochem/physiol Actions
Mode of Action: Polymyxin B Sulfate binds to the lipid A portion of bacterial lipopolysaccharides†, disrupting the cytoplasmic membrane by inducing pores large enough to permit nucleotide leakage in bacterial walls. This disrupts the permeability of the cytoplasmic membrane.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Antimicrobial spectrum: Has bactericidal action on most gram-negative bacilli††, including E. Coli and on most fungi and gram-positive bacteria.
Packaging
This product is packaged in a bottomless glass bottle, with its contents inside an inserted fused cone.
Caution
As supplied, the product should be stored at 2-8°C in the dark. No change was observed in retained samples after three years′ of storage in these conditions. Stock solutions should be sterile filtered and stored at 2-8°C. They are stable at 37°C for 5 days.
signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral
Storage Class
11 - Combustible Solids
wgk_germany
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Certificados de análisis (COA)
Lot/Batch Number
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Los clientes también vieron
Martti Vaara et al.
The Journal of antimicrobial chemotherapy, 73(2), 452-455 (2017-11-18)
Extremely multiresistant strains of Enterobacteriaceae, such as those of Escherichia coli and Klebsiella pneumoniae, are emerging and spreading at a worrisome speed. Polymyxins (polymyxin B, colistin) are used as last-line therapy against such strains, in spite of their notable nephrotoxicity
Mei-Ling Han et al.
ACS chemical biology, 13(1), 121-130 (2017-11-29)
Polymyxins are last-line antibiotics against life-threatening multidrug-resistant Gram-negative bacteria. Unfortunately, polymyxin resistance is increasingly reported, leaving a total lack of therapies. Using lipidomics and transcriptomics, we discovered that polymyxin B induced lipid A deacylation via pagL in both polymyxin-resistant and
Martti Vaara et al.
Peptides, 91, 8-12 (2017-03-17)
Recent years have brought in an increased interest to develop improved polymyxins. The currently used polymyxins, i.e. polymyxin B and colistin (polymyxin E) are pentacationic lipopeptides that possess a cyclic heptapeptide part with three positive charges, a linear "panhandle" part
Amit Kumar et al.
Scientific reports, 7, 39925-39925 (2017-01-05)
To become clinically effective, antimicrobial peptides (AMPs) should be non-cytotoxic to host cells. Piscidins are a group of fish-derived AMPs with potent antimicrobial and antiendotoxin activities but limited by extreme cytotoxicity. We conjectured that introduction of cationic residue(s) at the
Angelo Frei et al.
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New antibiotics and innovative approaches to kill drug-resistant bacteria are urgently needed. Metal complexes offer access to alternative modes of action but have only sparingly been investigated in antibacterial drug discovery. We have developed a light-activated rhenium complex with activity
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I see that you list several Polymyxin B Sulfate products (P0972, P1004, P4932, 81334 and P4119). What are the differences?
1 answer-
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What is MU and how does this relate to milligrams?
1 answer-
MU is million units. You can convert this to mg by dividing package size by the unit activity listed on the Certificate of Analysis for your specific lot.
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What is the solution stability of Product P0972, Polymyxin B sulfate?
1 answer-
For solution stability information, please refer to the product information sheet for a related Polymyxin B sulfate product (Product No. P1004).
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What is the Department of Transportation shipping information for this product?
1 answer-
Transportation information can be found in Section 14 of the product's (M)SDS.To access the shipping information for this material, use the link on the product detail page for the product.
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