MABT153

Anti-Aggrecan Antibody

mouse monoclonal, 4D7.1

• Sinónimos: Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1
• Código UNSPSC: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

Propiedades

• Nombre del producto: Anti-Aggrecan Antibody (full length), clone 4D7.1, clone 4D7.1, 1 mg/mL, from mouse
• origen biológico: mouse
• Nivel de calidad: 100
• forma del anticuerpo: purified antibody
• tipo de anticuerpo: primary antibodies
• clon: 4D7.1, monoclonal
• reactividad de especies: human
• concentración: 1 mg/mL
• técnicas: western blot: suitable
• isotipo: IgG1κ
• Nº de acceso NCBI: NP_037359
• Nº de acceso UniProt: P16112
• Condiciones de envío: wet ice
• modificación del objetivo postraduccional: unmodified
• Información sobre el gen: human ... ACAN(176)

Descripción

Descripción general

Aggrecan is an extracellular protein that is also known as Aggrecan core protein, Cartilage-specific proteoglycan core protein (CSPCP), Chondroitin sulfate proteoglycan core protein 1, and Chondroitin sulfate proteoglycan 1. Aggrecan is encoded by the gene ACAN/AGC1/CSPG1/MSK16. Aggrecan is a proteoglycan that is a major component of the extracellular matrix of cartilaginous tissues. The major function of Aggrecan is to resist compression in cartilage, thus providing protection for joint movement and against injury. Aggrecan binds various other ECM proteins via its large globular domains. Aggrecan can be cleaved into Aggrecan core protein 2, a C-terminal fragment component that decreases in cartilage as people age. Aggrecan is expressed in cartilage and is a massive (>2500 kDa) proteoglycan protein that has multiple isoforms. The appearance of Aggrecan fragments in the blood is a marker for various joint diseases.

Inmunógeno

KLH-conjugated linear peptide corresponding to human Aggrecan.

Aplicación

Research Category
Cell Structure

Research Sub Category
ECM Proteins

This Anti-Aggrecan Antibody (full length), clone 4D7.1 is validated for use in Western Blotting for the detection of Aggrecan (full length).

Calidad

Evaluated by Western Blotting in human chondrocyte cell lysate.

Western Blotting Analysis: 2 µg/mL of this antibody detected Aggrecan (full length) in 10 µg of human chondrocyte cell lysate.

Descripción de destino

~270 kDa observed. The calculated molecular weight is 250 kDa However, this protein is known to be highly glycosylated and may be observed at higher molecular weights.

Forma física

Format: Purified

Protein G Purified

Purified mouse monoclonal IgG1κ in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Almacenamiento y estabilidad

Stable for 1 year at 2-8°C from date of receipt.

Cláusula de descargo de responsabilidad

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Información de seguridad

• Código de clase de almacenamiento: 12 - Non Combustible Liquids
• Clase de riesgo para el agua (WGK): WGK 1
• Punto de inflamabilidad (°F): Not applicable
• Punto de inflamabilidad (°C): Not applicable