5.06239

Bupropion Hydrochloride

• Sinónimos: Bupropion Hydrochloride, Dopamine and noradrenalin Transporter Inibitor, Bupropion
• Fórmula empírica (notación de Hill): C₁₃H₁₈ClNO · xHCl
• Número CAS: 31677-93-7
• Peso molecular: 239.74 (free base basis)
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00055209
• Assay: ≥99% (HPLC)
• Form: solid
• Storage condition: OK to freeze, protect from light

Propiedades

• assay: ≥99% (HPLC)
• Quality Segment: 100
• form: solid
• potency: 1.4 μM K_i
• manufacturer/tradename: Calbiochem^®
• storage condition: OK to freeze, protect from light
• color: white
• solubility: water: soluble
• storage temp.: 2-8°C
• SMILES string: Clc1cc(ccc1)C(=O)C(NC(C)(C)C)C.Cl
• InChI: 1S/C13H18ClNO.ClH/c1-9(15-13(2,3)4)12(16)10-6-5-7-11(14)8-10;/h5-9,15H,1-4H3;1H
• InChI key: HEYVINCGKDONRU-UHFFFAOYSA-N

Descripción

General description

A non-selective inhibitor of dopamine and noradrenalin transporters (K_i = 1.4, 2.8 and 45 µM for dopamine, noradrenalin, and serotonin transporters respectively). Also an antagonist for neuronal nicotinic acetylcholine receptors (nAChrs) (IC₅₀ = 1.8 µM at α2β2 receptor). Clinically used as an antidepressant and smoking seceasion drug. Used in nicotinic addiction and depression studies.

Biochem/physiol Actions

Primary Target
DAT/NET

Preparation Note

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

Other Notes

Budzynska, B. et al. 2011 Pharmacol. Rep.63, 71.

Dwoskin, P., et al. 2006. CNS Drug Rev.12, 178.
Soroko, F., et al. 1977. J. Pharm. Pharmacol.29, 769.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

Información de seguridad

• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H302
• Indicaciones de precaución: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Clase de almacenamiento: 11 - Combustible Solids
• ¿Qué está pasando?: WGK 3
• Punto de inflamación (°F): Not applicable
• Punto de inflamación (°C): Not applicable