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215921

Chlorpromazine hydrochloride

Name: Chlorpromazine hydrochloride
Brand: MM

≥99% (HPLC), calmodulin-dependent phosphodiesterase inhibitor, crystalline solid

Sinónimos:

Chlorpromazine, Hydrochloride

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Fórmula empírica (notación de Hill):

C₁₇H₁₉ClN₂S · xHCl

Número CAS:

69-09-0

Peso molecular:

318.86 (free base basis)

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00012654

Assay:

≥99% (HPLC)

Form:

crystalline solid

Storage condition:

OK to freeze, desiccated (hygroscopic)

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Propiedades

Nombre del producto

Chlorpromazine, Hydrochloride, Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).

Quality Segment

100

description

Merck USA index - 14, 2185

assay

≥99% (HPLC)

form

crystalline solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze, desiccated (hygroscopic)

color

off-white

solubility

methanol: 10 mg/mL, water: 50 mg/mL

anion traces

sulfate (SO₄^2-): ≤0.05%

cation traces

Fe: ≤0.001%, heavy metals: ≤0.002%

shipped in

ambient

storage temp.

10-30°C

SMILES string

S1c2c(cc(cc2)Cl)N(c3c1cccc3)CCC[N+H](C)C.[Cl-]

InChI

1S/C17H19ClN2S.ClH/c1-19(2)10-5-11-20-14-6-3-4-7-16(14)21-17-9-8-13(18)12-15(17)20;/h3-4,6-9,12H,5,10-11H2,1-2H3;1H

InChI key

FBSMERQALIEGJT-UHFFFAOYSA-N

Descripción

General description

Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM). Acts as a peripheral vasodilator. An inhibitor of TNFα production. Inhibits nitric oxide synthase (NOS) in mouse brain and prevents lipopolysaccharide induction of NOS in murine lung. Shown to potently and specifically inhibit KSP/Eg5 (IC₅₀<10 µM), and PLA2.

Biochem/physiol Actions

Primary Target
Calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Product does not compete with ATP.

Target IC₅₀: 17 µM inhibiting calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase

Preparation Note

Following reconstitution, aliquot and freeze at -20°C. Stock solutions are stable for up to 6 months at -20°C and for up to 1 week at 4°C.

Other Notes

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Lee, M.S., et al. 2007. Cancer Res.67, 11359.
Maor, I., et al. 1995. Arteriosclero. Thromb. Vasc. Biol. 15, 1378.
Netea, M.G., et al. 1995. J. Infect. Dis. 171, 393.
Lindahl, M., and Tagesson, C. 1993. Inflammation17, 573.
Palacios, M., et al. 1993. Biochem. Biophys. Res. Commun. 196, 280.
Yamamoto, H. 1993. Toxicol. Lett. 66, 73.
Vadas, P., et al. 1986. Agents Actions19, 194.
Marshak, P.R., et al. 1985. Biochemistry24, 144.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Toxic (F)

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Este artículo	382425	129876	616382
Sigma-Aldrich 215921 Chlorpromazine, Hydrochloride	Sigma-Aldrich 382425 Trequinsin, Hydrochloride	Sigma-Aldrich 129876 Amiloride, Hydrochloride	Sigma-Aldrich 616382 N^α-Tosyl-Lys Chloromethyl Ketone, Hydrochloride
description Inhibits calmodulin-dependent stimulation of cyclic nucleotide phosphodiesterase (IC₅₀ = 17 µM).	description Extremely potent and cell-permeable inhibitor of cGMP-inhibited phosphodiesterase (IC₅₀ = 300 pM) and platelet aggregation in vitro.	description An inhibitor of angiogenesis.	description Inhibits trypsin-like serine proteinases.
assay ≥99% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥95% (elemental analysis)
form crystalline solid	form solid	form solid	form solid
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 10-30°C	storage temp. 10-30°C	storage temp. 10-30°C	storage temp. 2-8°C
storage condition desiccated (hygroscopic), OK to freeze	storage condition desiccated, OK to freeze	storage condition protect from light, desiccated (hygroscopic), OK to freeze	storage condition desiccated (hygroscopic), OK to freeze

Pictogramas

GHS06

Palabra de advertencia

Danger

Códigos de peligro

H301,H330

Hazard Classifications

Acute Tox. 1 Inhalation - Acute Tox. 3 Oral

Clase de almacenamiento

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Punto de inflamación (°F)

Not applicable

Punto de inflamación (°C)