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215911

Carbonyl Cyanide m-Chlorophenylhydrazone

Name: Carbonyl Cyanide <i>m</i>-Chlorophenylhydrazone
Brand: MM

≥95% (HPLC), solid, mitophagy inducer, Calbiochem

Sinónimos:

Carbonyl Cyanide m-Chlorophenylhydrazone, CCCP

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Número CAS:

555-60-2

UNSPSC Code:

12352200

NACRES:

NA.77

MDL number:

MFCD00001848

Assay:

≥95% (HPLC)

Form:

solid

Storage condition:

OK to freeze

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Propiedades

Nombre del producto

Carbonyl Cyanide m-Chlorophenylhydrazone, Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.

Quality Segment

100

description

RTECS - FG5600000

assay

≥95% (HPLC)

form

solid

manufacturer/tradename

Calbiochem^®

storage condition

OK to freeze

color

yellow

solubility

ethanol: 1 mg/mL, DMSO: 5 mg/mL

shipped in

ambient

storage temp.

2-8°C

SMILES string

Clc1cc(ccc1)NN=C(C#N)C#N

InChI

1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H

InChI key

UGTJLJZQQFGTJD-UHFFFAOYSA-N

Descripción

General description

Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol. Binds with cytochrome c oxidase with high affinity (K_d = 270 nM). Inhibits transport processes and depresses growth.

Biochem/physiol Actions

Cell permeable: no

Kd = 270 nM in binding with cytochrome c oxidase

Primary Target
cytochrome c oxydase

Product does not compete with ATP.

Reversible: no

Preparation Note

Following reconstitution, store in the refrigerator (4°C). Stock solutions are stable for up to 1 month at 4°C.

Other Notes

Bona, M., et al. 1993. Gen. Physiol. Biophys. 12, 533.
Heytler, P.G., and Prichard, W.W. 1962. Biochem. Biophys. Res. Commun.7, 272.

Legal Information

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

Toxicity: Harmful (C)

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Este artículo	390238	499610	525185
Sigma-Aldrich 215911 Carbonyl Cyanide m-Chlorophenylhydrazone	Sigma-Aldrich 390238 Camptothecin, 10-Hydroxy-, Camptotheca acuminata	Sigma-Aldrich 499610 (5Z)-7-Oxozeaenol, Curvularia sp.	Sigma-Aldrich 525185 Phospholipase C Activator, m-3M3FBS
description Protonophore. Uncoupling agent for oxidative phosphorylation that inhibits mitochondrial function. Approximately 100 times more effective than 2,4-dinitrophenol.	description A cell-permeable powerful DNA topoisomerase I inhibitor.	description (5Z)-7-Oxozeaenol, CAS 66018-38-0, is a cell-permeable, highly potent, selective, irreversible, and ATP-competitive inhibitor of MAPKKK TAK1 activity (IC₅₀ = 8 nM).	description The Phospholipase C Activator, m-3M3FBS, also referenced under CAS 200933-14-8, controls the biological activity of Phospholipase C. This small molecule/inhibitor is primarily used for Activators/Inducers applications.
form solid	form powder	form solid	form solid
assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)	assay ≥95% (HPLC)
manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®	manufacturer/tradename Calbiochem^®
Quality Level 100	Quality Level 100	Quality Level 100	Quality Level 100
storage temp. 2-8°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
storage condition OK to freeze	storage condition OK to freeze	storage condition protect from light, OK to freeze	storage condition protect from light, OK to freeze

pictograms

GHS06

signalword

Danger

hcodes

H301 + H311 + H331,H315,H319,H335

pcodes

P261 - P280 - P301 + P310 - P302 + P352 + P312 - P304 + P340 + P311 - P305 + P351 + P338

Hazard Classifications

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

target_organs

Respiratory system

Clase de almacenamiento

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

wgk

WGK 3

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