1.00886

Ethyl 4-hydroxybenzoate sodium salt

EMPROVE^® ESSENTIAL, Ph. Eur., BP, NF

• Sinónimos: Ethyl 4-hydroxybenzoate sodium salt, p-Hydroxybenzoic acid ethyl ester sodium salt, Ethylparaben sodium salt
• Fórmula empírica (notación de Hill): C₉H₉NaO₃
• Número CAS: 35285-68-8
• Peso molecular: 188.16
• MDL number: MFCD00016475
• UNSPSC Code: 12352108
• EC Index Number: 252-487-6
• eCl@ss: 32150319

Propiedades

• Quality Segment: 500
• agency: BP, NF, Ph. Eur.
• product line: EMPROVE^® ESSENTIAL
• form: solid
• pH: 10 (20 °C, 1 g/L in H₂O)
• bp: 297 °C/1013 hPa (free ester,decomposition)
• mp: >115 °C (free ester)
• transition temp: flash point 121 °C
• solubility: 1000 g/L
• application(s): liquid formulation; ophthalmics; pharmaceutical; solid formulation
• storage temp.: 15-25°C
• SMILES string: [Na+].[O-]c1ccc(cc1)C(=O)OCC
• InChI: 1S/C9H10O3.Na/c1-2-12-9(11)7-3-5-8(10)6-4-7;/h3-6,10H,2H2,1H3;/q;+1/p-1
• InChI key: QYNMSPKSYXPZHG-UHFFFAOYSA-M

Descripción

General description

Finding the right excipient that matches your needs as well as regulatory demands can be a complicated challenge in formulation. With our application know-how and regulatory expertise, we support you in every step of development, scale-up, and production. Our SAFC^® portfolio of high-quality products for biopharmaceutical and pharmaceutical formulation and production withstands strict quality control procedures and is produced according to applicable cGMP guidelines.

Application

Ethyl 4-hydroxybenzoate has antimicrobial characteristics and is used as preservative in pharmaceutical formulations and cosmetics. It can be combined with other parabens like methyl 4-hydroxybenzoate or propyl 4-hydroxybenzoate. The sodium salt provides improved solubility in water compared to standard ethyl 4-hydroxybenzoate.

Legal Information

Emprove is a registered trademark of Merck KGaA, Darmstadt, Germany

SAFC is a registered trademark of Merck KGaA, Darmstadt, Germany

Disclaimer

The product is not intended for use as a biocide under global biocide regulations, including but not limited to the US EPA′s Federal Insecticide Fungicide and Rodenticide Act, the European Biocidal Products Regulation, Canada’s Pest Management Regulatory Agency, Turkey’s Biocidal Products Regulation, Korea’s Consumer Chemical Products and Biocide Safety Management Act (K-BPR), and others.

Información de seguridad

• Clase de almacenamiento: 11 - Combustible Solids
• WGK: WGK 1
• Punto de inflamación (°F): 249.8 °F
• Punto de inflamación (°C): 121 °C
• Pictogramas: GHS07
• Palabra de advertencia: Warning
• Códigos de peligro: H319
• Indicaciones de precaución: P264 - P280 - P305 + P351 + P338 - P337 + P313
• Hazard Classifications: Eye Irrit. 2