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Merck

A-907

Supelco

alpha-Hydroxyalprazolam solution

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

Fórmula empírica (notación de Hill):
C17H13ClN4O
Número de CAS:
Peso molecular:
324.76
Número CE:
Número MDL:
Código UNSPSC:
41116107
NACRES:
NA.24

grado

certified reference material

Formulario

liquid

Características

SNAP-N-SPIKE®, SNAP-N-SHOOT®

envase

ampule of 1 mL

fabricante / nombre comercial

Cerilliant®

concentración

1.0 mg/mL in methanol

técnicas

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

aplicaciones

clinical testing

Formato

single component solution

temp. de almacenamiento

2-8°C

cadena SMILES

OCc1nnc2CN=C(c3ccccc3)c4cc(Cl)ccc4-n12

InChI

1S/C17H13ClN4O/c18-12-6-7-14-13(8-12)17(11-4-2-1-3-5-11)19-9-15-20-21-16(10-23)22(14)15/h1-8,23H,9-10H2

Clave InChI

ZURUZYHEEMDQBU-UHFFFAOYSA-N

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Descripción general

A major urinary metabolite of the benzodiazepine alprazolam. Alprazolam, commonly sold under the trade name Xanax®, is a short-acting anxiolytic approved to treat panic and other anxiety disorders including generalized or social anxiety disorder. This certified Snap-N-Spike® solution standard is suitable for use in LC/MS or GC/MS applications such as forensic analysis, clinical toxicology, urine drug testing, or pain prescription monitoring.

Información legal

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
Xanax is a registered trademark of Pharmacia & Upjohn Company

Palabra de señalización

Danger

Clasificaciones de peligro

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

Órganos de actuación

Eyes,Central nervous system

Código de clase de almacenamiento

3 - Flammable liquids

Clase de riesgo para el agua (WGK)

WGK 2

Punto de inflamabilidad (°F)

49.5 °F - closed cup

Punto de inflamabilidad (°C)

9.7 °C - closed cup


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[Pharmacological studies on alprazolam, and its main metabolites, alpha-OH-alprazolam and HB compound (author's transl)].
M Abe et al.
Igaku kenkyu. Acta medica, 50(7), 495-507 (1980-10-01)
Casey Jl Johnson et al.
Bioanalysis, 3(20), 2303-2310 (2011-10-21)
Conventional liquid-handling devices were employed, along with an improved punching device, to semi-automate dried blood spot (DBS) extraction of alprazolam, α-hydroxyalprazolam and midazolam from human whole blood. Liquid-handling devices were used to add internal standard to the DBS cards and
A D Fraser et al.
Journal of analytical toxicology, 17(7), 427-431 (1993-11-01)
Adinazolam is a triazolobenzodiazepine, currently under clinical investigation, that possesses antidepressant and anxiolytic activity. It has a short half-life (less than 3 h), and less than 2% of an oral dose is excreted unchanged. The major urinary metabolite is N-desmethyladinazolam
Hadi Molanaei et al.
European journal of clinical pharmacology, 68(5), 571-577 (2011-12-14)
To investigate the impact of persistent inflammation in hemodialysis (HD) patients on the pharmacokinetics of alprazolam, a cytochrome P450 (CYP) 3A4 substrate, and its metabolites and the role of HD in the impact of persistent inflammation in this clinical context.
A J Jenkins et al.
Journal of analytical toxicology, 21(3), 218-220 (1997-05-01)
Alprazolam is one of the most widely prescribed benzodiazepines in the United States. It is generally considered a safe and effective drug for the treatment of anxiety disorders and panic attacks. Few overdoses that are due to the sole ingestion

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