700056P
Avanti
lathosterol-d7
Avanti Research™ - A Croda Brand
Sinónimos:
5α-Cholest-7-en-3β-ol (25,26,26,26,27,27,27-d7)
Iniciar sesiónpara Ver la Fijación de precios por contrato y de la organización
About This Item
Fórmula empírica (notación de Hill):
C27H39D7O
Número de CAS:
Peso molecular:
393.70
Número MDL:
Código UNSPSC:
41141804
NACRES:
NA.25
Productos recomendados
Ensayo
>99% (TLC)
Formulario
powder
envase
pkg of 1 × 1 mg (700056P-1mg)
fabricante / nombre comercial
Avanti Research™ - A Croda Brand
Condiciones de envío
dry ice
temp. de almacenamiento
−20°C
Descripción general
Lathosterol is a metabolite of cholesterol present in human breast milk. Lathosterol is catabolized by lathosterol 5-desaturase to 7-dehydrocholesterol, which is a precursor of cholesterol. Lathosterol-d7 is a deuterated derivative of lathosterol.
Aplicación
Lathosterol-d7 has been used as an internal standard in gas chromatography-mass spectrometry (GC–MS) for the breast milk sterol quantification and in liquid chromatography high resolution mass spectrometry (LC–HRMS) analysis.
Acciones bioquímicas o fisiológicas
Lathosterol levels are direct indicators of cholesterol levels and aid in decoding metabolism defects. Elevated levels of lathosterol is implicated in cerebrotendinous xanthomatosis (CTX) and lathosterolosis. The inactivation of enzyme lathosterol 5-desaturase (SC5D) leads to accumulation of lathosterol in lathosterolosis pathology.
Envase
5 mL Amber Glass Screw Cap Vial (700056P-1mg)
Información legal
Avanti Research is a trademark of Avanti Polar Lipids, LLC
Código de clase de almacenamiento
11 - Combustible Solids
Punto de inflamabilidad (°F)
No data available
Punto de inflamabilidad (°C)
No data available
Elija entre una de las versiones más recientes:
Certificados de análisis (COA)
Lot/Batch Number
It looks like we've run into a problem, but you can still download Certificates of Analysis from our Documentos section.
Si necesita más asistencia, póngase en contacto con Atención al cliente
¿Ya tiene este producto?
Encuentre la documentación para los productos que ha comprado recientemente en la Biblioteca de documentos.
Patrycja A Krakowiak et al.
Human molecular genetics, 12(13), 1631-1641 (2003-06-19)
Lathosterol 5-desaturase catalyzes the conversion of lathosterol to 7-dehydrocholesterol in the next to last step of cholesterol synthesis. Inborn errors of cholesterol synthesis underlie a group of human malformation syndromes including Smith-Lemli-Opitz syndrome, desmosterolosis, CHILD syndrome, CDPX2 and lathosterolosis. We
Alan H B Wu et al.
Clinica chimica acta; international journal of clinical chemistry, 430, 43-47 (2014-01-08)
The analysis of blood for β-sitosterol and campesterol is the measures of cholesterol absorption while lathosterol is a measure of cholesterol synthesis. The biological variability of β-sitosterol, campesterol, and lathosterol was measured using liquid-chromatography tandem mass spectrometry from a cohort
Monica Gelzo et al.
Lipids in health and disease, 18(1), 235-235 (2020-01-01)
Cerebrotendinous xanthomatosis (CTX) and Lathosterolosis represent two treatable inherited disorders of cholesterol metabolism that are characterized by the accumulation of cholestanol and lathosterol, respectively. The age of the patients suspected of having these disorders is highly variable due to the
Andrea Civra et al.
The Journal of steroid biochemistry and molecular biology, 193, 105424-105424 (2019-07-16)
Oxysterols are cholesterol oxidation derivatives. Those containing an additional hydroxyl group on the side chain of the cholesterol molecule result from a physiological enzymatic synthesis and include the majority of oxysterols present in the circulation. Among these, 25-hydroxycholesterol (25OHC) and
Nuestro equipo de científicos tiene experiencia en todas las áreas de investigación: Ciencias de la vida, Ciencia de los materiales, Síntesis química, Cromatografía, Analítica y muchas otras.
Póngase en contacto con el Servicio técnico