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Merck
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Documentos

O9808

Sigma-Aldrich

2-Oxindole

97%

Sinónimos:

Oxindole

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About This Item

Fórmula empírica (notación de Hill):
C8H7NO
Número de CAS:
59-48-3
Peso molecular:
133.15
Beilstein/REAXYS Number:
114692
EC Number:
200-429-5
MDL number:
MFCD00005711
UNSPSC Code:
12352100
PubChem Substance ID:
24898074
NACRES:
NA.22

Quality Level

100

assay

97%

form

crystals

bp

227 °C/73 mmHg (lit.)

mp

123-128 °C (lit.)

SMILES string

O=C1Cc2ccccc2N1

InChI

1S/C8H7NO/c10-8-5-6-3-1-2-4-7(6)9-8/h1-4H,5H2,(H,9,10)

InChI key

JYGFTBXVXVMTGB-UHFFFAOYSA-N

Gene Information

human ... PGR(5241)

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Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves

Certificados de análisis (COA)

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5-(trifluoromethyl)oxindole AldrichCPR

Sigma-Aldrich

CDS008597

5-(trifluoromethyl)oxindole

Isatin 97%

Sigma-Aldrich

114618

Isatin

C Lanzi et al.
International journal of cancer, 85(3), 384-390 (2000-02-01)
ret-derived oncogenes are frequently and specifically expressed in thyroid tumors. In contrast to the ret receptor, ret oncoproteins are characterized by ligand-independent tyrosine-kinase activity and tyrosine phosphorylation. In this study, novel synthetic arylidene 2-indolinone compounds were evaluated as inhibitors of
Morteza Bararjanian et al.
The Journal of organic chemistry, 75(9), 2806-2812 (2010-04-15)
An efficient palladium-catalyzed protocol for the synthesis of 3-arylidene-2-oxindoles has been developed. In this approach, a sequential one-pot six-component reaction via Ugi/Heck carbocyclization/Sonogashira/nucleophilic addition was used for the synthesis of the desired skeleton.
Xianjie Chen et al.
Organic letters, 15(8), 1846-1849 (2013-04-09)
An asymmetric organo- and gold-catalyzed one-pot sequential Mannich/hydroamination reaction has been developed. Using this protocol, spiro[pyrrolidin-3,2'-oxindole] derivatives were synthesized in good yields (up to 91%) and excellent enantioselectivities (up to 97% ee).
Rahul R Khanwelkar et al.
Bioorganic & medicinal chemistry, 18(13), 4674-4686 (2010-06-24)
A series of new ureidoindolin-2-one derivatives were synthesized and evaluated as inhibitors of receptor tyrosine kinases. Investigation of structure-activity relationships at positions 5, 6, and 7 of the oxindole skeleton led to the identification of 6-ureido-substituted 3-pyrrolemethylidene-2-oxindole derivatives that potently
Yong-Jin Wua et al.
Current medicinal chemistry, 12(4), 453-460 (2005-02-22)
During the past five years, several members of the KCNQ potassium channel gene family have been identified with a high degree of CNS specificity. Within the KCNQ family, the combination of the KCNQ2/KCNQ3 proteins, and the KCNQ5/KCNQ3 arrangement has been
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