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Merck

919012

Sigma-Aldrich

PEI Prime linear polyethylenimine

suitable for gene delivery

Sinónimos:

PEI

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About This Item

Fórmula lineal:
(C2H5N . HCl)n
Número de CAS:
MDL number:
UNSPSC Code:
12162002
NACRES:
NA.23

Quality Level

form

powder

color

white to off-white

storage temp.

2-8°C

Application

PEI Prime is a cationic polymer designed for high-yield, reproducible and scalable drug and gene delivery. As a gene carrier, PEI forms a complex with nucleic acids via electrostatic self-assembly between the negatively charged nucleic acid phosphate groups and positively charged PEI amine groups. Due to this interaction, PEI has been extensively explored as a gene carrier and is one of the most effective synthetic polymers for the delivery of nucleic acids into cells through endocytosis.


PEI Prime uses an optimized form of PEI to reduce performance variance and speed process development time. Each batch of PEI Prime undergoes triplicate, quantitative performance testing using an SEAP reporter assay. PEI Prime is an excellent choice to produce any biologic cost-effectively, including recombinant proteins, antibodies, and viruses.

Legal Information

PEI Prime is a trademark of Serochem LLC

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable


Certificados de análisis (COA)

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S M Zou et al.
The journal of gene medicine, 2(2), 128-134 (2000-05-16)
Several nonviral vectors including linear polyethylenimine (L-PEI) confer a pronounced lung tropism to plasmid DNA when injected into the mouse tail vein in a nonionic solution. and results We have optimized this route by injecting 50 microg DNA with excess
W T Godbey et al.
Biomaterials, 22(5), 471-480 (2001-02-24)
Poly(ethylenimine) (PEI) was used to transfect the endothelial cell line EA.hy 926, and the secreted levels of three gene products, tissue-type plasminogen activator (tPA), plasminogen activator inhibitor type 1 (PAI-1), and von Willebrand Factor (vWF), were assessed via ELISA. We
L Wightman et al.
The journal of gene medicine, 3(4), 362-372 (2001-09-01)
Efficient gene transfer is a major challenge for non-viral gene therapy. Understanding how non-viral vectors initiate gene expression could lead to the development of new future vectors with enhanced efficacy. Linear or branched polyethylenimine (PEI)/DNA complexes were generated in varying

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