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Merck

207713

Sigma-Aldrich

1,3-Di-o-tolylguanidine

99%

Sinónimos:

DTG

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About This Item

Fórmula lineal:
(CH3C6H4NH)2C(=NH)
Número de CAS:
Peso molecular:
239.32
EC Number:
MDL number:
UNSPSC Code:
12352100
PubChem Substance ID:
NACRES:
NA.22

Quality Level

assay

99%

form

solid

mp

176-178 °C (lit.)

solubility

water: soluble 70 mg/mL at 20 °C

SMILES string

Cc1ccccc1NC(=N)Nc2ccccc2C

InChI

1S/C15H17N3/c1-11-7-3-5-9-13(11)17-15(16)18-14-10-6-4-8-12(14)2/h3-10H,1-2H3,(H3,16,17,18)

InChI key

OPNUROKCUBTKLF-UHFFFAOYSA-N

Gene Information

human ... EBP(10682)

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General description

1,3-Di-o-tolylguanidine is a selective σ-receptor agonist. 1,3-Di-o-tolylguanidine is σ site ligand and its interaction with dopamine drugs were studied in Wistar rats and Albino Swiss mice.

pictograms

Exclamation mark

signalword

Warning

hcodes

Hazard Classifications

Acute Tox. 4 Oral

Storage Class

11 - Combustible Solids

wgk_germany

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Faceshields, Gloves


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Previous studies demonstrated the effectiveness of selective σ-receptor (σR) agonists [1,3-di-o-tolylguanidine (DTG), PRE-084] as reinforcers in rats trained to self-administer cocaine. Similar to cocaine, these drugs increased nucleus accumbens shell dopamine levels, and effects of DTG, but not PRE-084, on

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