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X1126

Sigma-Aldrich

Xylazine

≥99%

Synonym(s):

2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine

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About This Item

Empirical Formula (Hill Notation):
C12H16N2S
CAS Number:
7361-61-7
Molecular Weight:
220.33
EC Number:
230-902-1
MDL number:
MFCD00057908
UNSPSC Code:
12352200
PubChem Substance ID:
24902128
NACRES:
NA.77

Assay

≥99%

storage temp.

−20°C

SMILES string

Cc1cccc(C)c1NC2=NCCCS2

InChI

1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)

InChI key

BPICBUSOMSTKRF-UHFFFAOYSA-N

General description

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

Application

Xylazine has been used to anaesthetise experimental animals.

Biochem/physiol Actions

Xylazine when used along with ketamine is considered to be a potent and safe anaesthetic in experimental animal. It is known to elevate the hepatic release of glucose, which aggravates to hyperglycemia.
α2-adrenoceptor agonist, sedative, muscle relaxant.

Pictograms

Skull and crossbones
GHS06

Signal Word

Danger

Hazard Statements

H301

Precautionary Statements

P301 + P310

Hazard Classifications

Acute Tox. 3 Oral

Storage Class Code

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Acute reversible cataract induced by xylazine and by ketamine-xylazine anesthesia in rats and mice
Calderone L, et al.
Experimental Eye Research, 42(4), 331-337 (1986)
Imaging of rat optic nerve axons in vivo
Koch JC, et al.
Nature Protocols, 6(12), 1887-1887 (2011)
Naomi Van Gassen et al.
European journal of immunology, 45(5), 1482-1493 (2015-02-04)
Pancreas injury by partial duct ligation (PDL) activates a healing response, encompassing β-cell neogenesis and proliferation. Macrophages (MΦs) were recently shown to promote β-cell proliferation after PDL, but they remain poorly characterized. We assessed myeloid cell diversity and the factors
Lactobacillus casei addition to a repletion diet-induced early normalisation of cytokine profils during a pneumococcal infection in malnourished mice
Salva S, et al.
Food and agricultural immunology, 19(3), 195-211 (2008)
Hannah T Nickles et al.
American journal of physiology. Lung cellular and molecular physiology, 307(1), L27-L37 (2014-05-13)
The pathogenesis of ventilator-induced lung injury has predominantly been attributed to overdistension or mechanical opening and collapse of alveoli, whereas mechanical strain on the airways is rarely taken into consideration. Here, we hypothesized that mechanical ventilation may cause significant airway
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