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Merck

Solid-phase synthesis of C-terminal azapeptides.

Journal of peptide science : an official publication of the European Peptide Society (2014-11-18)
Ngoc-Duc Doan, Jinqiang Zhang, Mariam Traoré, Winnie Kamdem, William D Lubell
PMID25400083
ABSTRACT

The solid-phase synthesis of azapeptides possessing a C-terminal aza-residue has been accomplished by a protocol featuring regioselective alkylation of benzhydrylidene-aza-glycinamide and illustrated by the syntheses of [aza-Lys(6)] growth-hormone-releasing peptide-6 analogs.

MATERIALI
N° Catalogo
Marchio
Descrizione del prodotto
270970
Sigma-Aldrich
Piridina, anhydrous, 99.8%
D125806
Sigma-Aldrich
N,N-diisopropiletilammina, ReagentPlus®, ≥99%
387649
Sigma-Aldrich
N,N-diisopropiletilammina, purified by redistillation, 99.5%
471216
Sigma-Aldrich
Diethylamine, ≥99.5%
225827
Sigma-Aldrich
N,N′-Disuccinimidyl carbonate, ≥95%
431362
Sigma-Aldrich
Hydroxylamine hydrochloride, 99.999% trace metals basis
531480
Sigma-Aldrich
Fmoc-Ala-OH, 95%
379921
Sigma-Aldrich
Hydroxylamine hydrochloride, 99.995% trace metals basis
W296600
Sigma-Aldrich
Piridina, ≥99%
B83606
Sigma-Aldrich
4-Methylbenzyl bromide, 97%
31730
Sigma-Aldrich
Diethylamine, puriss. p.a., ≥99.5% (GC)
386456
Sigma-Aldrich
Diethylamine, purified by redistillation, 99.5%
B60800
Sigma-Aldrich
1-Bromo-4-chlorobutane, 99%
47378
Sigma-Aldrich
Fmoc-D-Phe-OH, ≥98.0%
15449
Sigma-Aldrich
Boc-His(Trt)-OH, ≥98.0% (TLC)
B9602
Sigma-Aldrich
Benzophenone hydrazone, 96%
47309
Sigma-Aldrich
Fmoc-D-Trp(Boc)-OH, ≥95.0% (HPLC)