1396309

Metformin hydrochloride

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: 1,1-Dimethylbiguanide hydrochloride, Metformin
• Formula condensata: NH₂C(=NH)NHC(=NH)N(CH₃)₂ · HCl
• Numero CAS: 1115-70-4
• Peso molecolare: 165.62
• Numero MDL: MFCD00012582
• Codice UNSPSC: 41116107
• ID PubChem: 329750380
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: metformin
• Produttore/marchio commerciale: USP
• Punto di fusione: 223-226 °C (lit.)
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Stringa SMILE: Cl[H].CN(C)C(=N)NC(N)=N
• InChI: 1S/C4H11N5.ClH/c1-9(2)4(7)8-3(5)6;/h1-2H3,(H5,5,6,7,8);1H; OETHQSJEHLVLGH-UHFFFAOYSA-N

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia. For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Metformin hydrochloride USP reference standard for specified tests and assay use.

Also used to prepare standard, mixed standard stock and system suitability solutions for the assay, impurity analysis and performance tests according to the given below monographs of United States Pharmacopeia (USP):

• Metformin Hydrochloride
• Pioglitazone and Metformin Hydrochloride Tablets
• Metformin Hydrochloride Tablets
• Glyburide and Metformin Hydrochloride Tablets

Azioni biochim/fisiol

Metformin is an antidiabetic agent that reduces blood glucose levels and improves insulin sensitivity. Its metabolic effects, including the inhibition of hepatic gluconeogenesis, are mediated at least in part by activation of the LKB1-AMPK (AMP-activated protein kinase) pathway. Activation of this pathway also appears to be involved in the antiproliferative and proapoptotic actions of metformin in cancer cell lines.

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H319
• Consigli di prudenza: P264 - P280 - P301 + P312 - P305 + P351 + P338 - P337 + P313 - P501
• Classi di pericolo: Acute Tox. 4 Oral - Eye Irrit. 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable