1356971

Letrozole

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: 4,4′-(1H-1,2,4-Triazol-1-ylmethylene)bisbenzonitrile
• Formula empirica (notazione di Hill): C₁₇H₁₁N₅
• Numero CAS: 112809-51-5
• Peso molecolare: 285.30
• Numero MDL: MFCD00866241
• Codice UNSPSC: 41116107
• ID PubChem: 329750236
• NACRES: NA.24

Proprietà

• Grado: pharmaceutical primary standard
• Famiglia di API: letrozole
• Produttore/marchio commerciale: USP
• applicazioni: pharmaceutical (small molecule)
• Formato: neat
• Stringa SMILE: N#CC(C=C1)=CC=C1C(N2C=NC=N2)C3=CC=C(C#N)C=C3
• InChI: 1S/C17H11N5/c18-9-13-1-5-15(6-2-13)17(22-12-20-11-21-22)16-7-3-14(10-19)4-8-16/h1-8,11-12,17H; HPJKCIUCZWXJDR-UHFFFAOYSA-N
• Informazioni sul gene: human ... CYP19A1(1588)

Descrizione

Descrizione generale

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Applicazioni

Letrozole USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia. Also, for use with USP monographs such as:

• Letrozole Tablets

Azioni biochim/fisiol

Letrozole is a third generation nonsteroidal aromatase inhibitor. It is a competitive inhibitor of the aromatase enzyme system and thus inhibits the conversion of androgens to estrogens. Letrozole inhibits the aromatase enzyme by competitively binding to the heme of the cytochrome P450 subunit of the enzyme, resulting in a reduction of estrogen biosynthesis in all tissues.

Risultati analitici

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Altre note

Sales restrictions may apply.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Avvertenze: Warning
• Indicazioni di pericolo: H361fd,H373
• Consigli di prudenza: P202 - P260 - P280 - P308 + P313 - P405 - P501
• Classi di pericolo: Repr. 2 - STOT RE 2
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable