1286413

Frovatriptan succinate

United States Pharmacopeia (USP) Reference Standard

• Sinonimo/i: Frovatriptan succinate monohydrate, Frovatriptan succinate, R-(+) 3-Methylamino-6-carboxamido-1,2,3,4-tetrahydrocarbazole monosuccinate monohydrate
• Formula empirica (notazione di Hill): C₁₄H₁₇N₃O · C₄H₆O₄ · H₂O
• Numero CAS: 158930-17-7
• Peso molecolare: 379.41
• NACRES: NA.24
• PubChem Substance ID: 329749910
• UNSPSC Code: 41116107
• MDL number: MFCD18251278
• eCl@ss: 25140904

Proprietà

• grade: pharmaceutical primary standard
• agency: USP
• API family: frovatriptan
• manufacturer/tradename: USP
• application(s): pharmaceutical (small molecule); pharmaceutical; pharmaceutical
• format: neat
• SMILES string: OC(CCC(O)=O)=O.NC(C(C=C1)=CC2=C1NC3=C2C[C@H](NC)CC3)=O.O
• InChI: 1S/C14H17N3O.C4H6O4.H2O/c1-16-9-3-5-13-11(7-9)10-6-8(14(15)18)2-4-12(10)17-13;5-3(6)1-2-4(7)8;/h2,4,6,9,16-17H,3,5,7H2,1H3,(H2,15,18);1-2H2,(H,5,6)(H,7,8);1H2/t9-;;/m1../s1
• InChI key: CUETXFMONOSVJA-KLQYNRQASA-N
• Gene Information: human ... HTR1B(3351), HTR1D(3352)

Descrizione

General description

Find answers to frequently asked questions on USP products in USP FAQs.

This product is provided as delivered and specified by the issuing Pharmacopoeia. All information provided in support of this product, including SDS and any product information leaflets have been developed and issued under the Authority of the issuing Pharmacopoeia.
For further information and support please go to the website of the issuing Pharmacopoeia.

Application

Frovatriptan succinate USP reference standard, intended for use in specified quality tests and assays as specified in the USP compendia.

Biochem/physiol Actions

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Frovatriptan has high affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower with a pEC₅₀ value of 8.2 for the 5-HT1B receptor, compared to a pEC₅₀ value of 6.2 for the 5-HT7 receptor.

Frovatriptan is a serotonin 5HT-1B/1D-receptor agonist.

Analysis Note

These products are for test and assay use only. They are not meant for administration to humans or animals and cannot be used to diagnose, treat, or cure diseases of any kind.  ​

Other Notes

Sales restrictions may apply.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable