T2255

Trifluorothymidine

≥99% (HPLC), synthetic, powder

• Sinonimo/i: α,α,α-Trifluorothymidine, 2′-Deoxy-5-trifluoromethyluridine, Trifluorothymine deoxyriboside, Trifluridine
• Formula empirica (notazione di Hill): C₁₀H₁₁F₃N₂O₅
• Numero CAS: 70-00-8
• Peso molecolare: 296.20
• NACRES: NA.51
• PubChem Substance ID: 24900027
• UNSPSC Code: 41106305
• EC Number: 200-722-8
• MDL number: MFCD00006534
• Assay: ≥99% (HPLC)
• Biological source: synthetic
• Form: powder
• Solubility: water: 50 mg/mL, clear, colorless
• Storage temp.: −20°C

Proprietà

• Nome del prodotto: Trifluorothymidine, ≥99% (HPLC)
• biological source: synthetic
• Quality Segment: 100
• assay: ≥99% (HPLC)
• form: powder
• mp: 190-193 °C (lit.)
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)N2C=C(C(=O)NC2=O)C(F)(F)F
• InChI: 1S/C10H11F3N2O5/c11-10(12,13)4-2-15(9(19)14-8(4)18)7-1-5(17)6(3-16)20-7/h2,5-7,16-17H,1,3H2,(H,14,18,19)/t5-,6+,7+/m0/s1
• InChI key: VSQQQLOSPVPRAZ-RRKCRQDMSA-N

Descrizione

Application

Trifluorothymidine has been used as a component of selection medium to screen thymidine kinase (TK) mutants in lymphoma cells, human lymphoblastoid TK6 cells, and L5178Y mouse lymphoma cells.

Biochem/physiol Actions

Trifluorothymidine is a thymidine analog and is light sensitive. TFT serves as a thymidine kinase substrate to study enzyme specificity and kinetics. Incorporation of phosphorylated TFT into DNA induces damage, making it useful for DNA repair studies. TFT may also be used in the inhibition of thymidylate synthase and in screening mutant thymidine kinase gene.. It elicits antitumor activity in gastrointestinal (GI) cancers and has therapeutic potential to treat herpetic keratitis.

Packaging

Bottomless glass bottle. Contents are inside inserted fused cone.

Informazioni sulla sicurezza

• pictograms: GHS08
• signalword: Warning
• hcodes: H341,H351,H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Carc. 2 - Muta. 2 - Repr. 2
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves