T0910
Thioredoxin from Escherichia coli
recombinant, expressed in E. coli, essentially salt-free, lyophilized powder, ≥3 units/mg protein
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1 MG
CHF 282.00
About This Item
Prodotti consigliati
Origine biologica
Escherichia coli
Livello qualitativo
Ricombinante
expressed in E. coli
Saggio
≥90% (SDS-PAGE)
Stato
essentially salt-free, lyophilized powder
Attività specifica
≥3 units/mg protein
PM
11.7 kDa
tecniche
activity assay: suitable
Solubilità
water: 1.90-2.10 mg/mL, clear, colorless
N° accesso ID proteina
N° accesso UniProt
applicazioni
cell analysis
Temperatura di conservazione
−20°C
Informazioni sul gene
Escherichia coli K12 ... trxA(948289)
Descrizione generale
Research area: Cell Signaling
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.[1]
Thioredoxin from Escherichia coli is a monomeric, globular protein. It has a central β-sheet surrounded by α-helices.[1]
Applicazioni
Thioredoxin from Escherichia coli has been used in thioredoxin reductase assay, peroxidase-coupled thioredoxin system assay and peroxiredoxin assay.[2][3][4] It has also been used to study its effects on photoreceptor death in a mouse model of retinitis pigmentosa (RP) and its potential to modify retinal oxidative stress, glial changes, and vascular changes during the progression of the disease.[5]
Azioni biochim/fisiol
Mediates the reduction of disulfide bonds in proteins.
Thioredoxin from Escherichia coli catalyzes REDOX reactions and has a role in various biological processes. It modulates the structure and activity of many proteins. The enzyme thioredoxin reductase catalyzes the reduction of thioredoxin. Thioredoxin also has a role in oxidative stress response.[1][6][7]Thioredoxin, known as both adult T cell leukemia-derived factor (ADF) and a cellular redox enzyme, functions as a cytokine or chemokine, facilitating cell-to-cell communication.[8] Additionally, it plays a role in regulating cell growth and apoptosis.[9]
Altre note
GenBank® Accession Number M26133.
Definizione di unità
One unit will cause a ΔA650 of 1.0 in 1 min at 25 °C in the insulin reduction assay.
Note legali
GenBank is a registered trademark of United States Department of Health and Human Services
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
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Mechanism and structure of thioredoxin reductase from Escherichia coli.
Williams CH Jr
Faseb Journal, 9(13), 1267-1276 (1995)
Thioredoxin Delays Photoreceptor Degeneration, Oxidative and Inflammation Alterations in Retinitis Pigmentosa
Gimeno-Hernandez R, et al.
Frontiers in Pharmacology, 11 (2020)
Cell Signaling with Extracellular Thioredoxin and Thioredoxin-Like Proteins: Insight into Their Mechanisms of Action
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Oxidative Medicine and Cellular Longevity (2017)
Thioredoxin from Escherichia coli as a Role Model of Molecular Recognition, Folding, Dynamics and Function.
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Protein and peptide letters, 22(9), 801-815 (2015)
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