T0397

L-Thyroxine sodium salt pentahydrate

γ-irradiated, powder, BioXtra, suitable for cell culture

• Sinonimo/i: 3-[4-(4-Hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]-L-alanine sodium salt, Sodium levothyroxine, T₄
• Formula condensata: HOC₆H₂I₂OC₆H₂I₂CH₂CH(NH₂)COONa · 5H₂O
• Numero CAS: 6106-07-6
• Peso molecolare: 888.93
• UNSPSC Code: 12352209
• NACRES: NA.77
• PubChem Substance ID: 24899887
• EC Number: 200-221-4
• Beilstein/REAXYS Number: 5721845
• MDL number: MFCD00149110
• Biological source: synthetic (organic)
• Form: powder
• Assay: ≥98%

Proprietà

• biological source: synthetic (organic)
• Quality Segment: 200
• sterility: γ-irradiated
• product line: BioXtra
• assay: ≥98%
• form: powder
• potency: 5-50 ng/mL
• technique(s): cell culture | mammalian: suitable
• mp: 207-210 (dec.) (lit.)
• solubility: cell culture medium: 0.1 mg/mL, H₂O: soluble
• storage temp.: −20°C
• SMILES string: O.O.O.O.O.[Na+].N[C@@H](Cc1cc(I)c(Oc2cc(I)c(O)c(I)c2)c(I)c1)C([O-])=O
• InChI: 1S/C15H11I4NO4.Na.5H2O/c16-8-4-7(5-9(17)13(8)21)24-14-10(18)1-6(2-11(14)19)3-12(20)15(22)23;;;;;;/h1-2,4-5,12,21H,3,20H2,(H,22,23);;5*1H2/q;+1;;;;;/p-1/t12-;;;;;;/m0....../s1
• InChI key: JMHCCAYJTTWMCX-QWPJCUCISA-M
• Gene Information: mouse ... Cnr2(12802) ; rat ... Cnr1(25248)

Descrizione

Biochem/physiol Actions

L-Thyroxine (T₄) and triiodo-L-thyronine (T₃) are iodine-containing hormones produced from thyroglobulin in the thyroid follicular cells. The stimulation of metabolic rate and regulation of growth and development by these hormones appear to be due to their effects on DNA transcription and thus, protein synthesis.

Physical form

powder-0 °C; stock-frozen in working aliquots, avoid repeated freeze/thaw, solution stable 2-8 °C, 30 days

Preparation Note

To prepare 20 μg/ml stock solution, add 50 ml sterile culture medium.

Informazioni sulla sicurezza

• Pittogrammi: GHS08
• Parola di avvertenza: Danger
• Codici di pericolo: H372
• Avvertenze di sicurezza: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• Organi bersaglio: Thyroid,Cardio-vascular system,Kidney
• Classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable
• DPI (dispositivi di protezione individuale): Eyeshields, Gloves, type N95 (US)