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Documenti fondamentali

SRP6433

Sigma-Aldrich

PD-L1/CD274/B7-H1 from mouse

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

Sinonimo/i:

PDCD1L1, PDCD1LG1

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About This Item

Codice UNSPSC:
12352200
NACRES:
NA.32

Origine biologica

mouse

Ricombinante

expressed in HEK 293 cells

Tag

6-His tagged (C-terminus)

Saggio

≥95% (SDS-PAGE)

Stato

lyophilized

PM

calculated mol wt 25.6 kDa
observed mol wt 40-50 kDa (DTT-reduced. Protein migrates due to glycosylation. Phe 19 is the predicted N-terminal.)

Confezionamento

pkg of 10 and 50 μg

Impurezze

<1 EU/μg (LAL test)

N° accesso UniProt

Q9EP73

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... CD274(60533)

Descrizione generale

Programmed cell death 1 ligand 1 (PD-L1), which is also known as cluster of differentiation (CD274) or B7 homolog 1 (B7-H1), is a member of the growing B7 family of immune molecules. PD-L1 is a cell surface immunoglobulin with two Ig-like domains within the extracellular region and a short cytoplasmic domain. The protein is highly expressed in the heart, skeletal muscle, placenta and lung and weakly expressed in the thymus, spleen, kidney and liver. PD-L1 is expressed on activated T-cells, B-cells, dendritic cells, keratinocytes and monocytes.[1][2][3]

Azioni biochim/fisiol

Programmed cell death 1 ligand 1 (PD-L1) is involved in the regulation of cellular and humoral immune responses. PD-L1 is up-regulated on T- and B-cells, dendritic cells, keratinocytes and monocytes after lipopolysaccharide (LPS) and interferon-γ (IFNG) activation and up-regulated in B-cells activated by surface Ig cross-linking. PD-L1 is involved in the co-stimulatory signal, essential for T-cell proliferation and production of interleukin-10 (IL10) and IFNG, in an interleukin-2-dependent and a programmed cell death 1 (PDCD1)-independent manner.[4]

Stato fisico

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Normally Mannitol or Trehalose is added as protectants before lyophilization.

Ricostituzione

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
3F27L74280

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Intrinsic and extrinsic control of expression of the immunoregulatory molecule PD-L1 in epithelial cells and squamous cell carcinoma.
Ritprajak P and Azuma M
Oral Oncology, 51(3), 221-228 (2015)
Integrative analysis reveals selective 9p24.1 amplification, increased PD-1 ligand expression, and further induction via JAK2 in nodular sclerosing Hodgkin lymphoma and primary mediastinal large B-cell lymphoma.
Green MR
Blood, 116(17), 3268-3277 (2010)
The role of B7 family molecules in hematologic malignancy.
Greaves P and Gribben JG
Blood, 121(5), 734-744 (2013)
Adnan R Khan et al.
Nature communications, 6, 5997-5997 (2015-01-23)
Specific B-cell subsets can regulate T-cell immune responses, and are termed regulatory B cells (Breg). The majority of Breg cells described in mouse and man have been identified by IL-10 production and are known to suppress allergy and autoimmunity. However

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