SRP6067
Cyclophilin D human
recombinant, expressed in E. coli, ≥95% (SDS-PAGE)
Sinonimo/i:
CYP-40, CYPD, PPID, Peptidyl prolyl isomerase D
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About This Item
Codice UNSPSC:
12352200
NACRES:
NA.32
Prodotti consigliati
Origine biologica
human
Ricombinante
expressed in E. coli
Saggio
≥95% (SDS-PAGE)
Stato
liquid
PM
42.9 kDa
Confezionamento
pkg of 100 μg
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−70°C
Informazioni sul gene
human ... PPID(5481)
Descrizione generale
Cyclophilin D is a member of peptidyl-propyl cis-trans isomerase (PPIase) family. It is a mitochondrial matrix protein and a component of the mitochondrial permeability transition pore (MPTP).[1]
Applicazioni
Human cyclophilin D has been used to study the effects of muscle denervation on the opening of the permeability transition pore and on the expression of cyclophilin D in rats.[2]
Azioni biochim/fisiol
Cyclophilin D catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides[1] and accelerates the folding of proteins and thus their formation. It plays a decisive role in mitochondrial permeability transition. The protein can bind to the immunosuppressant cyclosporine A and its overexpression suppresses the apoptosis in cancer cells.[3]
Stato fisico
1 mg/mL solution in PBS (pH 7.4) containing 10% glycerol.
Nota sulla preparazione
Centrifuge the vial prior to opening.
Altre note
MGSSHHHHHH SSGLVPRGSH MSHPSPQAKP SNPSNPRVFF DVDIGGERVG RIVLELFADI VPKTAENFRA LCTGEKGIGH TTGKPLHFKG CPFHRIIKKF MIQGGDFSNQ NGTGGESIYG EKFEDENFHY KHDREGLLSM ANAGRNTNGS QFFITTVPTP HLDGKHVVFG QVIKGIGVAR ILENVEVKGE KPAKLCVIAE CGELKEGDDG GIFPKDGSGD SHPDFPEDAD IDLKDVDKIL LITEDLKNIG NTFFKSQNWE MAIKKYAEVL
Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Muscle denervation promotes opening of the permeability transition pore and increases the expression of cyclophilin D
Kristina Csukly
The Journal of Physiology (2006)
Giuseppe Federico Amodeo et al.
International journal of molecular sciences, 22(20) (2021-10-24)
The c subunit of the ATP synthase is an inner mitochondrial membrane (IMM) protein. Besides its role as the main component of the rotor of the ATP synthase, c subunit from mammalian mitochondria exhibits ion channel activity. In particular, c
Influence of cyclophilin D protein expression level on endothelial cell oxidative damage resistance.
Peng JZ
Genetics and molecular research : GMR, 14(2), 4258-4268 (2015)
Jeejabai Radhakrishnan et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 29(7), 2734-2748 (2015-04-04)
Cyclophilin-D (Cyp-D) is a mitochondrial matrix peptidyl-prolyl isomerase. Because cyclophilins can regulate nuclear gene expression, we examined whether Cyp-D could regulate mitochondrial gene expression. We demonstrated in HEK 293T cells that transfected Cyp-D interacts with mitochondrial transcription factors B1 and
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