Study enzyme kinetics, and screen small molecular inhibitors of Histone 3, K4,K9, methyltransferases for drug discovery and HTS applications
Stato fisico
Supplied as water solution, 800 μM
Nota sulla preparazione
Thaw on ice. Upon first thaw, briefly spin tube to recover full content of the tube. Aliquot into single use aliquots. Store remaining product in aliquots at -70°C. Note: Avoid freeze/thaw cycles.
Deposition of the major histone H3 (H3.1) is coupled to DNA synthesis during DNA replication and possibly DNA repair, whereas histone variant H3.3 serves as the replacement variant for the DNA-synthesis-independent deposition pathway. To address how histones H3.1 and H3.3
The histone variant H3.3 marks active chromatin by replication-independent nucleosome assembly.
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