SML3972
Azeliragon
≥98% (HPLC)
Sinonimo/i:
PF-04494700, PF04494700, 3-(4-{2-Butyl-1-[4-(4-chlorophenoxy)-phenyl]-1H-imidazole-4-yl}-phenoxy)-propyl]-diethylamine 1, 3-[4-[2-Butyl-1-[4-(4-chlorophenoxy)phenyl]imidazol-4-yl]phenoxy]-N,N-diethylpropan-1-amine), PF 04494700, TTP 488, TTP-488, TTP488
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Informazioni su questo articolo
Quality Segment
assay
≥98% (HPLC)
form
powder
color
, White to light brown
solubility
DMSO: 2 mg/mL, clear
storage temp.
room temp
SMILES string
Clc1ccc(cc1)Oc2ccc(cc2)[n]3c(nc(c3)c4ccc(cc4)OCCCN(CC)CC)CCCC
InChI
1S/C32H38ClN3O2/c1-4-7-9-32-34-31(25-10-16-28(17-11-25)37-23-8-22-35(5-2)6-3)24-36(32)27-14-20-30(21-15-27)38-29-18-12-26(33)13-19-29/h10-21,24H,4-9,22-23H2,1-3H3
InChI key
KJNNWYBAOPXVJY-UHFFFAOYSA-N
Biochem/physiol Actions
Azeliragon (PF-04494700; TTP488) is an orally active, brain-penetrant, selective receptor for advanced glycation end products (RAGE) antagonist (Kd = 12.7 nM using sRAGE; little affinity toward >100 receptors/transporters) that blocks known RAGE ligands binding (S100b, amphoterin, carboxymethyl-lysine, and Aβ1-42). Azeliragon (0.3-3 mg/kg/day p.o.) reduces brain amyloid (Aβ1-40 & Aβ1-42) and inflammatory markers (TNF-α, TGF-β and IL-1), while increases plasma Aβ in tgAPPSWE/LON mice, a mouse model with Swedish and London mutations that over-express human APP.
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Questo articolo | |||
|---|---|---|---|
| description ≥98% (HPLC) | description The RAGE Antagonist Peptide, RAP controls the biological activity of RAGE. | description ≥95% (HPLC) | description analytical standard |
| form powder | form powder | form (Powder or Lyophilized powder or film) | form - |
| assay ≥98% (HPLC) | assay ≥95% (HPLC) | assay ≥95% (HPLC) | assay - |
| Quality Level 100 | Quality Level 200 | Quality Level 100 | Quality Level 100 |
| storage temp. room temp | storage temp. −20°C | storage temp. -10 to -25°C | storage temp. - |
| solubility DMSO: 2 mg/mL, clear | solubility water: 5 mg/mL | solubility - | solubility - |
| color , White to light brown | color white | color white to off-white | color - |
Classe di stoccaggio
11 - Combustible Solids
Che succede?
WGK 3
Punto di infiammabilità (°F)
Not applicable
Punto di infiammabilità (°C)
Not applicable
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