SML3524

EtDO-P4

≥95% (HPLC)

• Sinonimo/i: D-EtDO-P4, D-threo-1-(3′,4′-Ethylenedioxy)phenyl-2-palmitoylamino-3-pyrrolidino-1-propanol, Ethylenedioxy-P4, N-[(1R,2R)-2-(2,3-Dihydro-1,4-benzodioxin-6-yl)-2-hydroxy-1-(1-pyrrolidinylmethyl)ethyl]hexadecanamide
• Formula empirica (notazione di Hill): C₃₁H₅₂N₂O₄
• Numero CAS: 245329-78-6
• Peso molecolare: 516.76
• UNSPSC Code: 51111800
• NACRES: NA.77
• Assay: ≥95% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: -10 to -25°C
• SMILES string: N3(CCCC3)C[C@@H](NC(=O)CCCCCCCCCCCCCCC)[C@H](O)c1cc2c(cc1)OCCO2
• InChI: 1S/C31H52N2O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-17-30(34)32-27(25-33-20-15-16-21-33)31(35)26-18-19-28-29(24-26)37-23-22-36-28/h18-19,24,27,31,35H,2-17,20-23,25H2,1H3,(H,32,34)/t27-,31-/m1/s1
• InChI key: BBTZZVJOQCCAOR-DLFZDVPBSA-N

Descrizione

Biochem/physiol Actions

Cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG)

EtDO-P4, a ceramide analog, is a cell penetrant, potent and selective nanomolar inhibitor of UDP-glucose ceramide glucosyltransferase (UGCG). Inhibition of UGCG by EtDO-P4 decreases drug resistance and enhances cytotoxicity of chemotherapeutic drugs such as vincristine, daunorubicin, Lucena-1 and cisplatin.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• WGK: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable