SML2950

E7820

≥98% (HPLC)

• Sinonimo/i: 3-Cyano-N-(3-cyano-4-methyl-1H-indol-7-yl)benzenesulfonamide, 3-Cyano-N-(3-cyano-4-methyl-1H-indole-7-yl)benzensulfonamide, E 7820, NSC 719239
• Formula empirica (notazione di Hill): C₁₇H₁₂N₄O₂S
• Numero CAS: 289483-69-8
• Peso molecolare: 336.37
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD09833234
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• ligand: E7820
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• reaction suitability: reagent type: ligand
• technique(s): targeted protein degradation: suitable
• color: white to beige
• solubility: DMSO: 2 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: [S](=O)(=O)(Nc2c3[nH]cc(c3c(cc2)C)C#N)c1cc(ccc1)C#N
• InChI: 1S/C17H12N4O2S/c1-11-5-6-15(17-16(11)13(9-19)10-20-17)21-24(22,23)14-4-2-3-12(7-14)8-18/h2-7,10,20-21H,1H3
• InChI key: LWGUASZLXHYWIV-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

E7820 (NSC 719239) is an orally available anticancer and antiangiogenic agent that inhibits VEGF-2 or FGF-2-induced tube formation of HUVEC cells through the suppression of integrin α2. E7820 promotes selective proteasomal degradation of the U2AF-related splicing factor CAPERα (coactivator of activating protein-1 and estrogen receptors) by ubiquitination and degradation via CRL4DCAF15.

inducer of selective proteasomal degradation of CAPERα

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• Che succede?: WGK 3
• Punto di infiammabilità (°F): Not applicable
• Punto di infiammabilità (°C): Not applicable