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Merck
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Documenti fondamentali

SML2859

Sigma-Aldrich

AB-1

≥98% (HPLC)

Sinonimo/i:

(1R,4R,5R)-rel-4-(4-Hydroxyphenyl)-6-methyl-3-oxabicyclo[3.3.1]non-6-ene-1-methanol, (1R,4R,5R)-rel-l-4-(5-(Hydroxymethyl)-8-methyl-3-oxabicyclo[3.3.1]non-7-en-2-yl))-phenol

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About This Item

Formula empirica (notazione di Hill):
C16H20O3
Numero CAS:
Peso molecolare:
260.33
Codice UNSPSC:
12352200
NACRES:
NA.77

Livello qualitativo

Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: 2 mg/mL, clear

Temperatura di conservazione

−20°C

Stringa SMILE

O1[C@H](C3C[C@](C1)(CC=C3C)CO)c2ccc(cc2)O

InChI

1S/C16H20O3/c1-11-6-7-16(9-17)8-14(11)15(19-10-16)12-2-4-13(18)5-3-12/h2-6,14-15,17-18H,7-10H2,1H3/t14?,15-,16+/m0/s1

Azioni biochim/fisiol

AB-1 is a highly selective estrogen receptors ERα and ERβ modulator over G protein-coupled estrogen receptor GPER. AB-1 is an agonist of ER transcriptional activity, but it acts as an antagonist of rapid signaling through ERα.
highly selective estrogen receptors ERα and ERβ modulator over G protein-coupled estrogen receptor GPER

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Robert W Hsieh et al.
The Journal of biological chemistry, 281(26), 17909-17919 (2006-05-02)
Estrogen receptors alpha (ERalpha) and beta (ERbeta) have distinct functions and differential expression in certain tissues. These differences have stimulated the search for subtype-selective ligands. Therapeutically, such ligands offer the potential to target specific tissues or pathways regulated by one
Chetana M Revankar et al.
Cell chemical biology, 26(12), 1692-1702 (2019-11-11)
Estrogen exerts extensive and diverse effects throughout the body of women. In addition to the classical nuclear estrogen receptors (ERα and ERβ), the G protein-coupled estrogen receptor GPER is an important mediator of estrogen action. Existing ER-targeted therapeutic agents act
Lawrence G Hamann et al.
Bioorganic & medicinal chemistry letters, 15(5), 1463-1466 (2005-02-17)
An oxabicyclic template for estrogen receptor alpha and beta agonists has been identified which can be tuned to provide moderate levels of selectivity for either receptor sub-type. Structure-activity relationships within this phenol-substituted oxabicyclo[3.3.1]nonene series are described. Select compounds from the

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