SML2657

MP-A08

≥98% (HPLC)

• Sinonimo/i: 4-Methyl-N-[2-[[[2-[[(4-methylphenyl)sulfonyl]amino]phenyl]imino]methyl]phenyl]benzenesulfonamide, NSC-122314
• Formula empirica (notazione di Hill): C₂₇H₂₅N₃O₄S₂
• Numero CAS: 219832-49-2
• Peso molecolare: 519.64
• Numero MDL: MFCD01053753
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to beige
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [S](=O)(=O)(Nc2c(cccc2)\N=C\c3c(cccc3)N[S](=O)(=O)c4ccc(cc4)C)c1ccc(cc1)C
• InChI: FLDBNMYJUMAXDQ-TURZUDJPSA-N

Descrizione

Azioni biochim/fisiol

ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2 (SphK 1 and 2)

MP-A08 is a highly selective ATP-competitive sphingosine kinase inhibitor that targets both SK1 and SK2. It is more selective and acts by different mechanisms than other SK inhibitors. MP-A0 targets the ATP-binding pocket, rather than the sphingosine binding pocket, with Ki values of 6.9 and 27 μM, respectively. Also, both SKI-II and PF-543 are thought to act in part by targeting sphingosine kinase for proteasomal degradation, which is not the case with MP-A08. MP-A08 was found to suppress the growth of human lung tumor xenografts in mice, both inducing apoptosis and inhibiting angiogenesis.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable