SML2560

OB-1

≥98% (HPLC)

• Sinonimo/i: Ethyl 5-(1-methyl-4-nitro-1H-imidazol-5-yloxy)-2-phenylbenzofuran-3-carboxylate
• Formula empirica (notazione di Hill): C₂₁H₁₇N₃O₆
• Numero CAS: 300803-69-4
• Peso molecolare: 407.38
• Numero MDL: MFCD01462999
• Codice UNSPSC: 12352200
• NACRES: NA.77

Proprietà

• Saggio: ≥98% (HPLC)
• Stato: powder
• Colore: white to very dark brown
• Solubilità: DMSO: 2 mg/mL, clear
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: [N+](=O)([O-])c1nc[n](c1Oc2cc3c([o]c(c3C(=O)OCC)c4ccccc4)cc2)C
• InChI: UJHGRDVYTTVJFD-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Inhibitor of Stomatin-like protein-3 (STOML3) oligomerization

OB-1 is an inhibitor of the oligomerization of Stomatin-like protein-3 (STOML3), which is a modulator of the mechanosensitive ion channel Piezo2. STOML3 requires oligomerization for its role as an endogenous regulator of the sensitivity of mechanosensitive Piezo ion channels in sensory neurons. By inhibiting this activity, OB-1 has been shown to reduce touch-evoked pain behavior in two mouse models of neuropathic pain.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable