SML2525

Tafluprost

≥98% (HPLC)

• Sinonimo/i: (5Z)-7-[(1R,2R,3R,5S)-2-[(1E)-3,3-Difluoro-4-phenoxy-1-buten-1-yl]-3,5-dihydroxycyclopentyl]-5-heptenoic acid 1-methylethyl ester, 16-phenoxy-15-deoxy-15,15-difluoro-17,18,19,20-tetranorprostaglandin F2α isopropyl ester, AFP-168
• Formula empirica (notazione di Hill): C₂₅H₃₄F₂O₅
• Numero CAS: 209860-87-7
• Peso molecolare: 452.53
• UNSPSC Code: 51111800
• NACRES: NA.77
• MDL number: MFCD08062150
• Assay: ≥98% (HPLC)
• Form: oil

Proprietà

• assay: ≥98% (HPLC)
• form: oil
• optical activity: [α]/D +20 to +25°, c = 1 in chloroform-d
• color: colorless to yellow
• storage temp.: −20°C
• SMILES string: FC(F)(COc2ccccc2)\C=C\C1C(CC(C1C\C=C\CCCC(=O)OC(C)C)O)O
• InChI: 1S/C25H34F2O5/c1-18(2)32-24(30)13-9-4-3-8-12-20-21(23(29)16-22(20)28)14-15-25(26,27)17-31-19-10-6-5-7-11-19/h3,5-8,10-11,14-15,18,20-23,28-29H,4,9,12-13,16-17H2,1-2H3/b8-3+,15-14+
• InChI key: WSNODXPBBALQOF-ZHDUIJGQSA-N

Descrizione

Biochem/physiol Actions

Prostaglandin F2α agonist; Antiglaucoma agent

Taflupost is a prostaglandin F2α agonist that lowers intraocular pressure and is used in the treatment of glaucoma. It has high affinity and selectivity for the fluoroprostaglandin (FP) receptor PGF2α. Tafluprost is believed to reduce the intraocular pressure (IOP) by increasing the outflow of aqueous humor. Tafluprost is a pro-drug. The active metabolite is the free acid.

Informazioni sulla sicurezza

• pictograms: GHS08
• signalword: Warning
• hcodes: H361d
• pcodes: P201 - P202 - P280 - P308 + P313 - P405 - P501
• Hazard Classifications: Repr. 2
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable