NSC23766 trihydrochloride has been used as a ras-related C3 botulinum toxin substrate 1 (RAC1) inhibitor.[1][2][3]
Azioni biochim/fisiol
NSC23766 is an inhibitor of Rac1, a Rho-family GTPase.
NSC23766 is an inhibitor of Rac1, a Rho-family GTPase. The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2.
Caratteristiche e vantaggi
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In elderly patients, bacterial infection often causes severe complications and sepsis. Compared to younger patients, older patients are more susceptible to sepsis caused by respiratory infection. Macrophage (Mϕ) phagocytosis of bacteria plays a critical role in the clearance of pathogens
Cyclic nucleotides like cAMP modulate cell function via PKA activation and ion channels.
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