SML0900

ZLN024

≥98% (HPLC)

• Sinonimo/i: 2-[[2-(2-Bromo-4-methylphenoxy)ethyl]thio]-pyrimidine
• Formula empirica (notazione di Hill): C₁₃H₁₃BrN₂OS
• Numero CAS: 723249-01-2
• Peso molecolare: 325.22
• UNSPSC Code: 12352202
• NACRES: NA.77
• Assay: ≥98% (HPLC)
• Form: powder

Proprietà

• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 20 mg/mL, clear
• storage temp.: 2-8°C
• SMILES string: S(CCOc2c(cc(cc2)C)Br)c1ncccn1
• InChI: 1S/C13H13BrN2OS/c1-10-3-4-12(11(14)9-10)17-7-8-18-13-15-5-2-6-16-13/h2-6,9H,7-8H2,1H3
• InChI key: KWJRSHZSULRJHE-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

ZLN024 is an allosteric activator of AMPK hetero-trimers.

ZLN024 is an allosteric activator of AMPK hetero-trimers. The compound ZLN024 protects against dephosphorylation of Thr172, which is critical for activity, and antagonizes AMPK autoinhibition. ZLM024 improves glucose tolerance and lowers total cholesterol levels in db/db mice.

Informazioni sulla sicurezza

• pictograms: GHS05,GHS07
• signalword: Danger
• hcodes: H302,H315,H318,H335
• pcodes: P280 - P301 + P312 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Hazard Classifications: Acute Tox. 4 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• target_organs: Respiratory system
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable