SML0350

AZD-7762 hydrochloride

≥98% (HPLC)

• Sinonimo/i: 5-(3-Fluorophenyl)-3-ureidothiophene-2-carboxylic acid N-[(S)-piperidin-3-yl]amide hydrochloride, AZD 7762 hydrochloride
• Formula empirica (notazione di Hill): C₁₇H₁₉FN₄O₂S · HCl
• Numero CAS: 1246094-78-9
• Peso molecolare: 398.88
• Numero MDL: MFCD12546135
• Codice UNSPSC: 12352200
• ID PubChem: 329825353
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: powder
• Condizioni di stoccaggio: desiccated
• Colore: white to light brown
• Solubilità: DMSO: 15 mg/mL, clear
• Temperatura di conservazione: −20°C
• Stringa SMILE: Cl.NC(=O)Nc1cc(sc1C(=O)N[C@H]2CCCNC2)-c3cccc(F)c3
• InChI: 1S/C17H19FN4O2S.ClH/c18-11-4-1-3-10(7-11)14-8-13(22-17(19)24)15(25-14)16(23)21-12-5-2-6-20-9-12;/h1,3-4,7-8,12,20H,2,5-6,9H2,(H,21,23)(H3,19,22,24);1H/t12-;/m0./s1; WFZBLOIXZRZEDG-YDALLXLXSA-N

Descrizione

Applicazioni

AZD-7762 hydrochloride has been used:

• as a checkpoint kinase 1 and 2 (CHK1/2) inhibitor to study its effect on the efficiency of non-homologous end-joining (NHEJ) repair in breast cancer cell lines[1]
• as a CHK1 inhibitor to serve as a positive control for replication stress in the assessment of fork restart events[2]
• as a CHK1/2 inhibitor to study its effects on DNA lesions during mice zygote development[3]

Azioni biochim/fisiol

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2 that enhanced cytotoxicity DNA-damaging agents.

AZD-7762 is a potent, ATP-competitive inhibitor of Chk1 and Chk2.

Informazioni sulla sicurezza

• Pittogrammi: GHS05,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H318
• Consigli di prudenza: P280 - P301 + P312 + P330 - P305 + P351 + P338 + P310
• Classi di pericolo: Acute Tox. 4 Oral - Eye Dam. 1
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable