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Merck
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SML0321

Sigma-Aldrich

Cyamemazine

≥98% (HPLC)

Sinonimo/i:

10-[3-(Dimethylamino)-2-methylpropyl]-10H-phenothiazine-2-carbonitrile, 7204 R. E., 7204 RP, Ciamatil, Cianatil, Cyamemazin, R.P. 7204, TH 2602

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About This Item

Formula empirica (notazione di Hill):
C19H21N3S
Numero CAS:
3546-03-0
Peso molecolare:
323.46
Numero CE:
222-594-2
Numero MDL:
MFCD00868180
Codice UNSPSC:
12352200
ID PubChem:
329825326
NACRES:
NA.77

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

light yellow to yellow-green

Solubilità

DMSO: ≥5 mg/mL

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(CN(C)C)CN1c2ccccc2Sc3ccc(cc13)C#N

InChI

1S/C19H21N3S/c1-14(12-21(2)3)13-22-16-6-4-5-7-18(16)23-19-9-8-15(11-20)10-17(19)22/h4-10,14H,12-13H2,1-3H3
SLFGIOIONGJGRT-UHFFFAOYSA-N

Applicazioni

Cyamemazine has been used as an internal standard and antipsychotic drug to spike plasma samples in mass spectrometry studies. It has also been used as an analytical standard in gas chromatography-tandem mass spectroscopic (GC-MS/MS) analysis.

Azioni biochim/fisiol

Cyamemazine belongs to the class of phenothiazine drugs. It is known to treat severe depression, schizophrenia and bipolar disorder.
Cyamemazine is a potent antagonist of 5-HT2C and 5-HT3 receptors with antipsychotic and anxiolytic properties.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H410

Consigli di prudenza

P273 - P391 - P501

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Débora Caramelo et al.
Analytical and bioanalytical chemistry, 411(23), 6141-6153 (2019-07-12)
The present work describes the optimization and validation of an analytical method for the determination of six antipsychotic drugs (chlorpromazine, levomepromazine, cyamemazine, clozapine, haloperidol, and quetiapine) in oral fluid samples after solvent extraction from dried saliva spots, by gas chromatography
Amine Benyamina et al.
European journal of pharmacology, 578(2-3), 142-147 (2007-10-16)
Animal and human pharmacological studies indicate that the antipsychotic action of cyamemazine results from blockade of dopamine D(2) receptors, its anxiolytic properties from serotonin 5-HT(2C) receptor antagonism and the low incidence of extrapyramidal side effects from a potent 5-HT(2A) receptor
William Crumb et al.
European journal of pharmacology, 532(3), 270-278 (2006-02-24)
The antipsychotic and anxiolytic phenothiazine, cyamemazine, was investigated for its effects on the hERG (human ether-à-go-go related gene) channel expressed in HEK 293 cells and on native INa, ICa, Ito, Isus, or IK1 of human atrial myocytes. Moreover, cyamemazine and
Cathy M Jacobs et al.
Analytical and bioanalytical chemistry, 413(6), 1729-1737 (2021-02-01)
Volumetric absorptive microsampling (VAMS), an emerging microsampling technique, is expected to overcome some disadvantages of dried blood spots such as volume inaccuracy and influence of hematocrit (HT). This study aimed to develop and evaluate a VAMS-based strategy for quantification of
Multi-trajectories of antidepressant and antipsychotic use: a 11-year naturalistic study in a community-based sample
<BIG>Verdoux H, et al.</BIG>
Acta Psychiatrica Scandinavica (2019)
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