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SML0245

Sigma-Aldrich

Candesartan cilexetil

≥98% (HPLC)

Sinonimo/i:

2-ethoxy-1-[[2′-(2H-tetrazol-5-yl)[1,1′-biphenyl]-4-yl]methyl]-1H-Benzimidazole-7-carboxylic acid 1-[[(cyclohexyloxy)carbonyl]oxy]ethyl ester, TCV 116, TCY 116

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CHF 98.00
50 MG
CHF 353.00

About This Item

Formula empirica (notazione di Hill):
C33H34N6O6
Numero CAS:
145040-37-5
Peso molecolare:
610.66
Numero MDL:
MFCD00871371
Codice UNSPSC:
12352200
ID PubChem:
329825255
NACRES:
NA.77

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Saggio

≥98% (HPLC)

Stato

powder

Colore

white to beige

Solubilità

DMSO: ≥15 mg/mL

Ideatore

Takeda

Temperatura di conservazione

2-8°C

Stringa SMILE

CCOc1nc2cccc(C(=O)OC(C)OC(=O)OC3CCCCC3)c2n1Cc4ccc(cc4)-c5ccccc5-c6nnn[nH]6

InChI

1S/C33H34N6O6/c1-3-42-32-34-28-15-9-14-27(31(40)43-21(2)44-33(41)45-24-10-5-4-6-11-24)29(28)39(32)20-22-16-18-23(19-17-22)25-12-7-8-13-26(25)30-35-37-38-36-30/h7-9,12-19,21,24H,3-6,10-11,20H2,1-2H3,(H,35,36,37,38)
GHOSNRCGJFBJIB-UHFFFAOYSA-N

Informazioni sul gene

human ... AGTR1(185)

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Azioni biochim/fisiol

Candesartan cilexetil is a non-peptide angiotensin (AT2) receptor antagonist.
Candesartan cilexetil is the prodrug form of the potent angiotensin II receptor antagonist, candesartan. The prodrug is cleaved by esterases within the intestine to liberate the active molecule.

Caratteristiche e vantaggi

This compound is featured on the Angiotensin Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Takeda. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360D,H373

Classi di pericolo

Repr. 1B - STOT RE 2 Oral

Organi bersaglio

Kidney,Blood

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

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Certificati d'analisi (COA)

Lot/Batch Number
0000236336
0000192981
113M4707V
072M4749V
012M4714V

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Candesartan cilexetil British Pharmacopoeia (BP) Reference Standard

BP1248

Candesartan cilexetil

Olmesartan ≥98% (HPLC)

Sigma-Aldrich

SML1394

Olmesartan

USP

USP

1087814

Candesartan cilexetil Related Compound A

Candesartan Cilexetil Impurity E Pharmaceutical Secondary Standard; Certified Reference Material

Supelco

PHR2036

Candesartan Cilexetil Impurity E

Azilsartan ≥98% (HPLC)

Sigma-Aldrich

SML0432

Azilsartan

Candesartan cilexetil for system suitability European Pharmacopoeia (EP) Reference Standard

Y0001389

Candesartan cilexetil for system suitability

Olmesartan medoxomil ≥98% (HPLC)

Sigma-Aldrich

SML1391

Olmesartan medoxomil

Telmisartan ≥98% (HPLC), solid

Sigma-Aldrich

T8949

Telmisartan

Geranylgeranylacetone

Sigma-Aldrich

G5048

Geranylgeranylacetone

Ji-Young Jeon et al.
Drug development and industrial pharmacy, 39(9), 1296-1299 (2012-10-04)
Candesartan is a long-acting and selective nonpeptide AT1 subtype angiotensin II receptor antagonist. The aim of this study was to compare the pharmacokinetics and to evaluate the bioequivalence of two candesartan cilexetil 16 mg formulations. Forty healthy volunteers were randomly assigned
J M Mallion et al.
Journal of human hypertension, 14 Suppl 2, S33-S41 (2000-11-22)
Candesartan is one of the first angiotensin II receptor antagonists (AIIRAs) to be developed. It binds tightly to and dissociates slowly from the angiotensin subtype 1 (AT1) receptor in vitro. These binding characteristics differ from those of losartan, which demonstrates
Ezequiel Balmori Melian et al.
Drugs, 62(5), 787-816 (2002-04-04)
The combination of candesartan cilexetil [an angiotensin II type 1 (AT(1)) receptor antagonist] plus hydrochlorothiazide (a thiazide diuretic), has been used in the treatment of patients with hypertension. The blood pressure (BP) lowering effect of various doses of this combination
Stephanie E Easthope et al.
Drugs, 62(8), 1253-1287 (2002-05-16)
Candesartan cilexetil is converted to the angiotensin II receptor antagonist candesartan during absorption from the gastrointestinal tract. The selective and competitive binding of candesartan to the angiotensin II type 1 (AT(1)) receptor prevents binding of angiotensin II, a key mediator
Sheridan M Hoy et al.
American journal of cardiovascular drugs : drugs, devices, and other interventions, 10(5), 335-342 (2010-09-24)
Candesartan cilexetil is the orally administered prodrug of candesartan, an angiotensin II subtype 1 receptor antagonist. The pharmacokinetics (area under the plasma concentration-time curve and maximum plasma concentration) of candesartan do not appear to be affected by age, sex, or
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