Placental alkaline phosphatase (PLAP) or ALPP is a phosphomonoesterase. It is expressed in the placenta and endometrium. The PLAP gene is localized on human chromosome 2q37.1.
Immunogeno
Recombinant protein encoding human placental alkaline phosphatase.
Azioni biochim/fisiol
Placental alkaline phosphatase (PLAP) or ALPP is a hydrolase, which is involved in the hydrolysis of phosphomonoesters. It has been shown to be a biomarker for ovarian cancer. The protein is expressed in carcinomas such as ovarian adenocarcinoma, dysgerminoma, serous cystadenocarcinoma and undifferentiated carcinoma.
Caratteristiche e vantaggi
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Stato fisico
0.1 ml rabbit monoclonal antibody supplied as tissue culture supernatant in TBS/1% BSA buffer pH 7.5 with less than 0.1% sodium azide.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Genome wide expression profile in human HTR-8/Svneo trophoblastic cells in response to overexpression of placental alkaline phosphatase gene.
Bellazi L
Placenta (2011)
A human monoclonal antibody specific to placental alkaline phosphatase, a marker of ovarian cancer.
Ravenni N
MAbs (2014)
Cloverleaf skull anomaly and de novo
trisomy 4p
Journal of medical Genetics (1999)
Refined structures of placental alkaline phosphatase show a consistent pattern of interactions at the peripheral site.
Stec B
Acta Crystallographica Section F, Structural Biology and Crystallization Communications (2010)
Human placental alkaline phosphatase-mediated hydrolysis correlates tightly with the electrostatic contribution from tail group.
Yang Y
Chemical Biology & Drug Design (2011)
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