SAB4504621

Anti-phospho-MER/SKY (pTyr^749/681) antibody produced in rabbit

affinity isolated antibody

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: rabbit
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Forma fisica: buffered aqueous solution
• PM: antigen 110 kDa
• Reattività contro le specie: human, rat, mouse
• Concentrazione: ~1 mg/mL
• tecniche: ELISA: 1:10000; immunohistochemistry: 1:50-1:100; western blot: 1:500-1:1000
• N° accesso NCBI: Q06418; Q12866
• N° accesso UniProt: Q06418
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: phosphorylation (pTyr749/pTyr681)
• Informazioni sul gene: human ... MERTK(10461) , TYRO3(7301)

Descrizione

Descrizione generale

Tyro3 (TYRO3 protein tyrosine kinase) is an 890 amino acid protein that belongs to the TAM (Tyro3, Axl and Mer) receptor family. Tyro3 is mapped to human chromosome 15q15. It is highly expressed in the nervous system like the neocortex, hippocampus and cerebellum. It is also present in monocytes, macrophages, platelets, dendritic cells and NK cells, breast, ovary, testis, lung, kidney, retinal pigment epithelium and osteoclasts.

Immunogeno

The antiserum was produced against synthesized peptide derived from human MER/SKY around the phosphorylation site of Tyr749/681.

Immunogen Range: 716-765

Azioni biochim/fisiol

Tyro3 (TYRO3 protein tyrosine kinase) serves as a therapeutic target in breast cancer. This protein is involved in spermatogenesis, immunoregulation, and phagocytosis. It controls disseminated prostate cancer cellular dormancy. TYRO3 helps in the survival and transport of of gonadotropin-releasing hormone (GnRH) neurons within the forebrain. Mutation in TYRO3 result in retinitis pigmentosa.

Caratteristiche e vantaggi

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Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable