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Documenti fondamentali

SAB4502029

Sigma-Aldrich

Anti-NPY2R antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

NPY-Y2 receptor, NPY2-R, NPY2R, Neuropeptide Y receptor type 2

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100 μG
CHF 582.00

CHF 582.00


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100 μG
CHF 582.00

About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

CHF 582.00


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Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 42 kDa

Reattività contro le specie

human, mouse, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:1000
immunofluorescence: 1:100-1:500
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... NPY2R(4887)

Descrizione generale

The NPY2R (neuropeptide Y receptor Y2) gene is mapped to human chromosome 4q32.1 and codes for a G-protein-coupled receptor. NPY2R is predominantly expressed in central nervous system including hypothalamus, brain stem, hippocampus, lateral septum and amygdala. NPY2 receptors are also distributed in the liver, spleen, intestine, adipose tissue and muscle.

Immunogeno

The antiserum was produced against synthesized peptide derived from human NPY2R.

Immunogen Range: 1-50

Azioni biochim/fisiol

NPY2R (neuropeptide Y receptor Y2) acts as a presynaptic autoreceptor and heteroreceptor. It regulates the release of both endogenous NPY and neurotransmitters such as glutamate and γ–aminobutyric acid (GABA). NPY exerts its anxiolytic function via the NPY2R. Deletion of NPY2R results in retardation of the anticonvulsant actions of NPY. NPY2R plays an important role in the process of bone formation.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Tao Yang et al.
Cellular & molecular biology letters, 28(1), 60-60 (2023-07-28)
Sebaceous glands (SGs) synthesize and secret sebum to protect and moisturize the dermal system via the complicated endocrine modulation. Dysfunction of SG are usually implicated in a number of dermal and inflammatory diseases. However, the molecular mechanism behind the differentiation
Unwinding of the C-Terminal Residues of Neuropeptide Y is critical for Y2 Receptor Binding and Activation.
Kaiser A
Angewandte Chemie (International Edition in English), 54(25), 7446-7449 (2015)
Debanjan Chakroborty et al.
British journal of cancer, 127(8), 1440-1449 (2022-07-29)
Resistance to anti-angiogenic therapies targeting vascular endothelial growth factor-A (VEGF-A) stems from VEGF-A independent angiogenesis mediated by other proangiogenic factors. Therefore identifying these factors in colon adenocarcinoma (CA) will reveal new therapeutic targets. Neuropeptide Y (NPY) and Y2 receptor (Y2R)
Viswanthram Palanivel et al.
Cells, 11(22) (2022-11-27)
Neuropeptide Y (NPY), a sympathetic neurotransmitter, is involved in various physiological functions, and its dysregulation is implicated in several neurodegenerative diseases. Glutamate excitotoxicity, endoplasmic reticulum (ER) stress, and oxidative stress are the common mechanisms associated with numerous neurodegenerative illnesses. The
Yuka Akagi et al.
FEBS open bio, 14(1), 63-78 (2023-11-28)
Food-derived biological signals are transmitted to the brain via peripheral nerves through the paracrine activity of gastrointestinal (GI) hormones. The signal transduction circuit of the brain-gut axis has been analyzed in animals; however, species-related differences and animal welfare concerns necessitate

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