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SAB4501220

Sigma-Aldrich

Anti-GLP1R antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

GLP-1 receptor, GLP-1-R, GLP-1R, GLP1R, Glucagon-like peptide 1 receptor

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 53 kDa

Reattività contro le specie

human, mouse

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:5000
immunofluorescence: 1:100-1:500

N° accesso NCBI

P43220

N° accesso UniProt

P43220

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... GLP1R(2740)

Descrizione generale

Anti-GLP1R Antibody detects endogenous levels of total GLP1R protein.
Glucagon-like peptide 1 receptor (GLP1R) protein belongs to the class B G protein-coupled receptor (GPCR) secretin family. This classic seven-transmembrane protein is abundantly expressed in the cardiovascular system. The GLP1R gene is located on the human chromosome 6p21. Anti-GLP1R Antibody detects endogenous levels of total GLP1R protein.

Immunogeno

The antiserum was produced against synthesized peptide derived from human GLP1R.

Immunogen Range: 101-150

Applicazioni

Anti-GLP1R antibody produced in rabbit has been used in immunofluorescence staining.

Azioni biochim/fisiol

Glucagon-like peptide 1 receptor (GLP1R) protein participates in the activation of protein kinase A (PKA), phosphoinositide 3-kinase (PI3K), MEK1/2, and endothelial nitric oxide synthase (eNOS) pathways. Hence, it plays a key role in apoptosis reduction, improved energy metabolism, decreased inflammation in myocardial cells, and vasodilation in myocardial arteries. The large N-terminal extracellular domain of GLP1R participates in ligand binding. Alterations in the GLP1R gene might increase the risk of coronary artery disease (CAD).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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Glucagon-like peptide 1 (GLP-1) bestows protective effects upon the cardiovascular system through direct cardiovascular interactions or by improvements to metabolic function. Both these effects are thought to be at least partly mediated by the GLP-1 receptor (GLP-1R). This case-controlled study

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