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SAB4500662

Sigma-Aldrich

Anti-Aggrecan (Cleaved-Asp369), N-Terminal antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

CSPCP, CSPG1, aggrecan core protein, cartilage-specific proteoglycan core protein, chondroitin sulfate proteoglycan core protein 1

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

PM

antigen 44 kDa

Reattività contro le specie

human, rat

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000

N° accesso NCBI

P16112

N° accesso UniProt

P16112

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

proteolytically cleaved (Asp369)

Informazioni sul gene

human ... ACAN(176)

Descrizione generale

Anti-Aggrecan (Cleaved-Asp369) Antibody detects endogenous levels of fragment of activated Aggrecan (Cleaved-Asp369) protein.
Aggrecan is a large aggregating chondroitin sulfate proteoglycan of the human cartilage. It is encoded by AGC1 (aggrecan) gene. It is located on human chromosome 15q26.1.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Aggrecan.

Immunogen Range: 320-369

Applicazioni

Anti-Aggrecan (Cleaved-Asp369), N-Terminal antibody has been used in western blotting and immunostaining.

Azioni biochim/fisiol

Mutations in aggrecan results in autosomal dominant short stature with accelerated skeletal maturation. Mutation in the variable repeat region of the aggrecan gene (AGC1) leads to spondyloepiphyseal dysplasia.

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Sigma-Aldrich

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A Mutation in the Variable Repeat Region of the Aggrecan Gene (AGC1) Causes a Form of Spondyloepiphyseal Dysplasia Associated with Severe, Premature Osteoarthritis
Lindsay G, et al.
American Journal of Human Genetics, 77(3), 484-490 (2005)
Feng-Lai Yuan et al.
Cell stress & chaperones, 21(1), 97-104 (2015-09-20)
Acidic conditions are present in degenerated intervertebral discs and are believed to be responsible for matrix breakdown. Acid-sensing ion channel 1a (ASIC1a) is expressed in endplate chondrocytes, and its activation is associated with endplate chondrocyte apoptosis. However, the precise role
Complete coding sequence and deduced primary structure of the human cartilage large aggregating proteoglycan, aggrecan. Human-specific repeats, and additional alternatively spliced forms.
Doege K J, et al.
The Journal of Biological Chemistry, 266(2), 894-902 (1991)
Clinical Characterization of Patients With Autosomal Dominant Short Stature due to Aggrecan Mutations.
Gkourogianni A, et al.
The Journal of Clinical Endocrinology and Metabolism, 102(2), 460-469 (2017)
Gene expression profiles of early chondrogenic markers in dedifferentiated fat cells stimulated by bone morphogenetic protein 4 under monolayer and spheroid culture conditions in vitro
Eiko A, et al.
Orthodontic Waves, 75(4), 97-104 (2016)
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