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Documenti fondamentali

SAB4500579

Sigma-Aldrich

Anti-Cytochrome P450 1A1 antibody produced in rabbit

affinity isolated antibody

Sinonimo/i:

AHH, AHRR, CP11, CYP1, CYPIA1

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

PM

antigen 58 kDa

Reattività contro le specie

rat, mouse, human

Concentrazione

~1 mg/mL

tecniche

ELISA: 1:20000
western blot: 1:500-1:1000

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... CYP1A1(1543)

Descrizione generale

Anti-Cytochrome P450 1A1 Antibody detects endogenous levels of total Cytochrome P450 1A1 protein.
The cytochrome P450 family 1 subfamily A member 1 (CYP1A1) gene with seven exons, is mapped to human chromosome 15q24.1. The encoded protein is primarily expressed in extrahepatic tissues.

Immunogeno

The antiserum was produced against synthesized peptide derived from human Cytochrome P450 1A1/2.

Immunogen Range: 71-120

Azioni biochim/fisiol

Cytochrome P450 family 1 subfamily A member 1 (CYP1A1) catalyzes 2-OH hydroxylation in the endometrium. In addition, it also catalyzes the oxidation of various structurally unrelated compounds, such as steroids and fatty acids. CYP family members play an important role in metabolic activation and detoxification of tobacco-derived carcinogen and other xenobiotics. CYP1A1 also facilitates drug metabolism. Mutation in the gene increases the risk of susceptibility to colorectal cancer and acute lymphoblastic leukemia (ALL).

Caratteristiche e vantaggi

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

Stato fisico

Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

nwg

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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CYP1A1, SULT1A1, and SULT1E1 polymorphisms are risk factors for endometrial cancer susceptibility.
Hirata H, et al.
Cancer, 112(9), 1964-1973 (2008)
Genetic polymorphisms of NQO1, CYP1A1 and TPMT and susceptibility to acute lymphoblastic leukemia in a Tunisian population.
Ouerhani S, et al.
Molecular Biology Reports, 40(2), 1307-1314 (2013)
CYP1A1 Ile462Val polymorphism contributes to colorectal cancer risk: A meta-analysis
Jin JQ, et al.
World Journal of Gastroenterology, 17(2), 260-260 (2011)
Allele and genotype frequencies of the polymorphic cytochrome P450 genes (CYP1A1, CYP3A4, CYP3A5, CYP2C9 and CYP2C19) in the Jordanian population.
Yousef AM, et al.
Molecular Biology Reports, 39(10), 9423-9433 (2012)
An additional case of the recurrent 15q24. 1 microdeletion syndrome and review of the literature.
Ng I S, et al.
Twin Research and Human Genetics : The Official Journal of the International Society for Twin Studies, 14(4), 333-339 (2011)

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