SAB4500112
Anti-C/EBP-β antibody produced in rabbit
affinity isolated antibody
Sinonimo/i:
AGP/EBP, C/EBP β, C/EBP-related protein 2, CCAAT/enhancer binding protein β, CEBPB
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About This Item
Prodotti consigliati
Origine biologica
rabbit
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
buffered aqueous solution
PM
antigen 36 kDa
Reattività contro le specie
human, rat, mouse
Concentrazione
~1 mg/mL
tecniche
ELISA: 1:10000
immunohistochemistry: 1:50-1:100
western blot: 1:500-1:1000
N° accesso NCBI
N° accesso UniProt
Condizioni di spedizione
wet ice
Temperatura di conservazione
−20°C
modifica post-traduzionali bersaglio
unmodified
Informazioni sul gene
human ... CEBPB(1051)
Descrizione generale
Anti-C/EBP-β Antibody detects endogenous levels of total C/EBP-β protein.
CCAAT/enhancer-binding protein-β (C/EBP-β) is encoded by the gene mapped to human chromosome 20q13.13. The encoded protein belongs to the C/EBP family. C/EBP-β is a leucine-zipper transcription factor and is highly expressed during the early stages of adipocyte development. Alternative splicing of C/EBP-β leads to the formation of three isoforms such as, C/EBPβ-1 with 346 amino acids, C/EBPβ-2 with 323 amino acid and C/EBPβ with 146 amino acids.
Immunogeno
The antiserum was produced against synthesized peptide derived from human C/EBP-beta.
Immunogen Range: 201-250
Immunogen Range: 201-250
Azioni biochim/fisiol
CCAAT/enhancer-binding proteins (C/EBPs) regulate expression of various cytokines and chemokines such as, interleukin-6 (IL-6), IL-8 and monocyte chemoattractant protein-1 (MCP-1). C/EBP-β plays a vital role in the regulation of gluconeogenesis and adipogenesis gene expression. The encoded protein also modulates the gene expression of human immunodeficiency virus-1 (HIV-1) and other retroviruses (human T-cell leukemia virus type (HTLV-) and simian immunodeficiency viruses (SIV)). This is carried out by regulating various process, like C-C chemokine receptor type 5 (CCR5) expression, virus promoter activities, cytokine and chemokine production and virus protein function. C/EBPβ is involved in various cellular processes such as metabolism, development and differentiation. Overexpression of C/EBP-β mRNA has been observed in various types of cancers.
Caratteristiche e vantaggi
Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.
Stato fisico
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
10 - Combustible liquids
Classe di pericolosità dell'acqua (WGK)
nwg
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
CCAAT/enhancer-binding proteins and the pathogenesis of retrovirus infection
Liu Y, et al.
Future Microbiology, 4, 299-321 (2009)
Genomic imbalances in Schistosoma-associated and non-Schistosoma-associated bladder carcinoma. An array comparative genomic hybridization analysis.
Armengol G
Cancer Genetics and Cytogenetics, 177, 16-19 (2007)
C/EBP?-1 promotes transformation and chemoresistance in Ewing sarcoma cells
Gardiner JD, et al.
Oncotarget, 8, 26013-26026 (2017)
Dan Liu et al.
Nature communications, 9(1), 1739-1739 (2018-05-02)
Chemoresistance is a major unmet clinical obstacle in ovarian cancer treatment. Epigenetics plays a pivotal role in regulating the malignant phenotype, and has the potential in developing therapeutically valuable targets that improve the dismal outcome of this disease. Here we
Keito Okazaki et al.
Nature communications, 11(1), 5911-5911 (2020-11-22)
Transcriptional dysregulation, which can be caused by genetic and epigenetic alterations, is a fundamental feature of many cancers. A key cytoprotective transcriptional activator, NRF2, is often aberrantly activated in non-small cell lung cancers (NSCLCs) and supports both aggressive tumorigenesis and
Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..
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